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ETS gene fusions have been characterized in a majority of prostate cancers, however key molecular alterations in ETS negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier-expression exclusively in a subset of ETS rearrangement negative cancers (~...
ORGANISM(S): Homo sapiens 
Homo sapiens Raw sequence reads of 22Rv1
The spliced variant forms of androgen receptor (AR-Vs) have been identified recently in castration-resistant prostate cancer (CRPC) cell lines and clinical samples. Here we identified the cistrome and transcriptome landscape of AR-Vs in CRPC cell lines and determine the clinical significance of AR v...
ORGANISM(S): Homo sapiens 
Rfx6 amplicon sequencing from genome edited 22Rv1 isogenic cell lines
Activation of the inflammatory circuits occurs frequently in cancer cells. However the molecular details linking inflammation to transformation and progression are still unknown. In this study we report for the first time, that activation of the ETS factor ESE1 is a key event connecting inflammatory...
ORGANISM(S): Homo sapiens 
To clarify the relationship between histone acetylation and miRNA expression, we performed miRNA arrays to detect histone deacetylase inhibitor (OBP-801) induced miRNA regulating AR expression in 22Rv1. Agilent-031181 Unrestricted Human miRNA Microarray (Agilent Technologies, Santa Clara, California...
ORGANISM(S): Homo sapiens 
Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
BRD4 ChIP-Seq in 22Rv1 cells exogenously expressing HNF4G or GFP
RNA sequencing in 22RV1 cells stably expressing shLuc, shIMPA1, shIMPDH2
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