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MetabolomicsMechanism of Hepatotoxicity Induced by Ethanol Extract of Emilia sonchifolia (L.) DC Revealed by Proteomics and Metabolomics

Objective: Hepatotoxicity has been reported for Emilia sonchifolia (L.) DC (Emilia sonchifolia). The plant material is typically prepared using two extraction methods for practical application: water extraction and ethanol extraction. However, our previous research only investigated its wate...

2025-10-30 | MTBLS13237 | MetaboLights
ProteomicsMembrane proteomics of Arabidopsis glucosinolate mutants cyp79B2/B3 and myb28/29
in our previous work we studied the molecular networks cotrolling their metabolism in Arabidopsis thaliana on the level of soluble proteome and metebolome using myb28/29 and cyp79B2/B3 as mutants for aliphilic and indollic glucosinolates production respectively.we go deeper to study the changes on t...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-19 | PXD005781 | Pride
Cyp79b2/b3 Tmt Membrane proteomics Myb28/29 
ProteomicsAllele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Birdshot chorioretinopathy (BSCR) is a rare inflammatory eye disease very strongly associated with HLA-A*29:02, with >95% of patients carrying this allele. BSCR is also associated with endoplasmic reticulum aminopeptidase (ERAP)2, an enzyme involved in processing HLA class I ligands. We analyzed the...
ORGANISM(S): Homo sapiens (Human) 
2018-05-17 | PXD007679 | Pride
Hla-a*29:02 Endoplasmic reticulum aminopeptidase 2 (erap2) Birdshot chorioretinopathy 
TranscriptomicsmRNA-Seq expression and MS3 proteomics profiling of human post-mortem BA9 brain tissue for Parkinson Disease and neurologically normal individuals
Parkinson disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy Bodies” within neurons. PD has both genetic and environmental risk factors, and while processes leading to aberrant protein aggregation ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-68719 | biostudies-arrayexpress
ProteomicsNew nodes and edges in the glucosinolate molecular network revealed by proteomics and metabolomics of Arabidopsis myb28/29 and cyp79B2/B3
In this project we aimed to investigate new connections (edges) in the glucosinolate metabolism molecular network. We studied proteome changes in myb28/29 and cyp79B2/B3 Arabidopsis thaliana mutants as an effect of glucosinolate metabolism perturbation.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-03-01 | PXD002284 | Pride
Proteomics Arabidopsis Cyp79b2/b3 Glucosinolate Brassicaceae Itraq Myb28/29 
TranscriptomicsTranscriptional profile of pimozide-treated cancer cell lines MIA PaCa-2, PANC-1, HT-29, HCT 116, SK-OV-3, OVCAR-5, AGS, MKN45 and DMSO-treated (as control)
DRD2 antagonists are commonly used clinically for the treatment of psychiatric disorders. This study aimed to explore the antitumor effects of DRD2 antagonists on a variety of tumor entities. A DRD2 antagonist, pimozide, exhibited antitumor effects in pancreatic, colorectal, ovarian, and gastric can...
ORGANISM(S): Homo sapiens 
2025-08-01 | E-MTAB-15350 | biostudies-arrayexpress
UnknownAccurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics.
Not available
S-EPMC6442365 | biostudies-literature
Proteomics29-Plex Tandem Mass Tag Mass Spectrometry Enabling Accurate Quantification by Interference Correction
Tandem mass tag (TMT) mass spectrometry is a mainstream isobaric chemical labeling strategy for profiling proteomes. Here we present a 29-plex TMT method to combine the 11-plex and 18-plex labeling strategies. The 29-plex method was examined with a pooled sample composed of 1x, 3x and 10x E. coli pe...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033865 | Pride
Mass spectrometry  liquid chromatography  proteomics  proteome  tandem mass tag  ratio compression  interference  data processing 
ProteomicsBLM-G4 pulldown IP-MS in human colon cancer HT-29 cells
the experiment uses biotin-labelled BLM-G4 to incubate with HT-29 cell lysates, and uses streptavidin agarose beads to pulldown BLM-G4-binding proteins. Utilize LC-MS/MS to annotate and quantify the proteins pulled down by BLM-G4.
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075345 | Pride
Pulldown Blm-g4 Ip-ms Ht-29 cell 
UnknownQuantitative proteomics-based analyses performed on pre-eclampsia samples in the 2004-2020 period: a systematic review.
Not available
S-EPMC7836571 | biostudies-literature
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