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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
ProteomicsQualityseed - Proteomic identification of quality factors for oocytes in the Pacific oyster Crassostrea gigas
Protein identification from 2D gels, spot 1........
ORGANISM(S): Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 
2016-12-02 | PRD000656 | Pride
TranscriptomicsMadin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.
In order to gain insight into epithelial morphogenesis and the influence of culture geometry on gene expression patterns, Madin Darby Canine Kidney (MDCK) epithelial cells where grown in 2-dimensional (2D) culture or 3-dimensional (3D) culture . MDCK cells cultured in 2D were plated atop a pre-soli...
ORGANISM(S): Canis lupus familiaris 
2013-06-03 | E-GEOD-28381 | biostudies-arrayexpress
ProteomicsComparative Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) of Human Milk to Identify Dysregulated Proteins in Breast Cancer
Breast Cancer (BC) remains a major cause of mortality, and early detection is considered important for reducing BC-associated deaths. Early detection of BC is challenging in young women, due to the limitations of mammography on the dense breast tissue of young women. We recently reported results of ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD009860 | Pride
Mass spectrometry Breast cancer Breast milk 2d-page Proteomics Biomarkers 
UnknownDynaProt 2D: an advanced proteomic database for dynamic online access to proteomes and two-dimensional electrophoresis gels.
Not available
S-EPMC540055 | biostudies-literature
UnknownHigh performance CCD camera system for digitalisation of 2D DIGE gels.
Not available
S-EPMC5095783 | biostudies-literature
ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins
The myosin light chain protein family consists of two classes, the regulatory myosin light chains (RLC) and the essential myosin light chains (ELC). Functionally, the MLC proteins are directly involved in sarcomeric activity and force transmission contributing to cardiac contractility. Besides regul...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD033908 | Pride
Cardiomyocytes Essential myosin light chains (elc) Phosphorylation Regulatory myosin light chains (rlc) 
Proteomics2D-DIGE global protein profiling of alcohol-dependent mouse brain
Data analysis. Spot detection and matching were performed with a comparative cross analysis of all the gels using DeCyder software v.6.5 (GE Healthcare). 178 spots were selected based on 1.15-fold for protein ratio cut-off, allowing for the appearance of the spots in 23 out of 28 gels (69 out of 8...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-28 | PXD000349 | Pride
Cie Mouse Brain Alcohol dependence Midbrain Cortex 2d-dige 
TranscriptomicsGenome-wide analysis of control and MMP-14 (MT1-MMP) expressing MCF-7 cells growing in three-dimensional (3D) type I collagen gels versus monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) and three-dimensional (3D) culture conditions on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (CTRL) or human MMP-14 cDNA ...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-49595 | biostudies-arrayexpress
UnknownAnalysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease.
Not available
S-EPMC8790928 | biostudies-literature
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