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MetabolomicsEffect of PARK7 gene KO on midbrain organoids
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ORGANISM(S): Homo sapiens 
ST002327 | MetabolomicsWorkbench
ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
GenomicsEnhancer landscape of mouse developing midbrain at 11.5 dpc embryos
We report the distribution of histone H3K4me1 and H3K27ac within the genome of mouse embryonic midbrain. We prepared the chromatin from 11 dpc embryonic midbrain and made chromatin precipitation with antibody against H3K4me1 and H3K27ac (rabbit polyclonal antibody). High-throughput sequencing appli...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-49652 | biostudies-arrayexpress
TranscriptomicsSingle nuclei chromatin profiles of midbrain from genetically distinct mouse strains reveal cell identity transcription factors and cell type-specific gene regulatory variation
Here we report 20 658 single nuclei chromatin accessibility profiles of ventral midbrain cell types from two genetically diverse and commonly used mouse strains, C57BL6/J and A/J. In total we identify over 260 000 unique accessible sites. The distinct chromatin profiles are consistent with gene expr...
ORGANISM(S): Mus musculus 
2022-01-14 | E-MTAB-9225 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile in embryonic mesencephalon and neuronal primary cultures
In the mammalian central nervous system (CNS) an important contingent of dopaminergic neurons are localized in the substantia nigra and in the ventral tegmental area of the ventral midbrain. They constitute an anatomically and functionally heterogeneous group of cells involved in a variety of regula...
ORGANISM(S): Rattus norvegicus 
2009-05-10 | E-GEOD-15920 | biostudies-arrayexpress
TranscriptomicsLoss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation
Background: Precise spatiotemporal control of gene expression is essential for the establishment of correct cell numbers and identities during brain development. This process involves epigenetic control mechanisms, such as those mediated by the polycomb group protein Ezh2 that catalyzes trimethylat...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-74538 | biostudies-arrayexpress
ProteomicsHuamn iPSC midbrain neuron Parkinson disease
Proteomic analysis of iPSC-midbrain neuron cultures from Parkinson's disease patients haboring A53T pathogenic variant
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD051673 | Pride
Synuclein Midbrain Ipsc Parkinsons disease 
GenomicsRING1B binding in the 11 dpc embryonic tissues
We report the distribution of RING1B (one of Polycomb group factors) within the genome of mouse embryonic tissues. We prepared the chromatin from 11 dpc embryonic forebrain, midbrain, and forelimb buds and made chromatin precipitation with antibody against RING1B (mouse monoclonal antibody). High-th...
ORGANISM(S): Mus musculus 
2014-01-14 | E-GEOD-48464 | biostudies-arrayexpress
TranscriptomicsDifferential expression between floor plate and ventral lateral region in E10.5 mouse embryo midbrain
The data revealed differential expression between floor plate and ventral lateral region in E10.5 mouse embryo midbrain. Several differentially expressed genes in these regions have been reported in the literature, demonstrating reliability of tissue dissection. Midbrain floor plate and non-overlapp...
ORGANISM(S): Mus musculus 
2011-05-18 | E-GEOD-25178 | biostudies-arrayexpress
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