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ProteomicsProteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-02-27 | PXD008297 | Pride
Proteomics Cho Keywords: biomanufacturing Necrosis Apoptosis 2d-lc-mse 
ProteomicsGlobal mapping of rat plasma proteins with a native proteomic approach using nondenaturing micro 2DE and label-free quantitative LC-MS/MS
Plasma samples from adult male rats were separated by nondenaturing micro 2DE and a representative gel was selected, on which a total of 136 CBB-stained spots were numbered and subjected to in-gel digestion and label-free quantitative LC-MSE (MS/MS in data-independent acquisition mode). The analysi...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-10-14 | PXD004395 | Pride
Native proteomics Adult male rat plasma proteome Nondenaturing micro 2de Global mapping Label-free quantitative lc-mse 
ProteomicsCharacterization of the rat hippocamus proteome
Rat brain tissue lysed, then analyzed by 2D-LC-MSE, processed with Elucidator and PLGS
ORGANISM(S): Rattus norvegicus (Rat) 
2011-02-01 | PRD000298 | Pride
ProteomicsRepurposing Farnesyltransferase Inhibitors Tipifarnib and Lonafarnib as Antibacterial Agents: Proteomic and Functional Analyses
Farnesyltransferase inhibitors (FTIs) such as tipifarnib and lonafarnib were originally developed as anticancer agents but have recently been reported to exhibit antibacterial activity against Gram-positive pathogens. The underlying antibacterial mechanism of action, however, remains unknown. Here, ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 Bacteria 
2026-09-14 | PXD081045 | Pride
Drug repurposing Mode of action Farnesyltransferase inhibitors Proteomics Antibiotics 
UnknownOffline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng.
Not available
S-EPMC7775852 | biostudies-literature
ProteomicsAnalysis of LDL-associated proteins using the method of digitized native protein mapping
The method of digitized native protein mapping, combining nondenaturing micro 2DE, grid gel-cutting and quantitative LC-MS/MS (in data-independent acquisition mode, or MSE), was improved by using a new MS/MS mode, ion mobility separation enhanced-MSE (HDMSE) and applied to analyze the area of human ...
ORGANISM(S): Homo sapiens (Human) 
2016-05-17 | PXD003720 | Pride
Grid gel-cutting Quantitative lc-hdmse Human plasma low-density lipoprotein Protein-protein interactions Nondenaturing micro 2de Digitized native protein mapping 
ProteomicsXcc Pan Proteome
In this project, two isolates of Xanthomonas campestris pv campestris were compared in the following conditions, 1. growth in NYG rich medium, and 2. growth in XVM1 minimal medium. Total proteins were extracted and trypsin digested. The nanoscale Liquid Chromatography was performed to separate trypt...
ORGANISM(S): Xanthomonas Campestris Pv. Campestris (ncbitaxon:340) 
2018-12-05 | MSV000083181 | MassIVE
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
ProteomicsProteomic response to the thaxtomin phytotoxin elicitor cellobiose and to the deletion of the cellulose utilization regulator CebR in Streptomyces scabies
Streptomyces scabies is a plant pathogen responsible for common scab disease on root and tuber crops. The transport of the cellulose by-products cellobiose and cellotriose into the cell induces the biosynthesis of the main phytotoxin thaxtomin A. These carbohydrates bind to the cis-acting sequences ...
ORGANISM(S): Streptomyces scabiei 87.22 
2018-10-18 | PXD007820 | Pride
Streptomyces scabies Lc-mse Pathogenicity Synapt ms 
ProteomicsThe acyl-proteome of Syntrophus aciditrophicus reveals metabolic relationship with benzoate degradation
Syntrophus aciditrophicus is a model syntrophic bacterium that degrades fatty and aromatic acids into acetate, CO2, formate and H2 that are utilized by methanogens and other hydrogen-consuming microbes. The degradation of benzoate by S. aciditrophicus proceeds by a multi-step pathway that involves m...
ORGANISM(S): Syntrophus aciditrophicus SB 
2022-03-16 | PXD025631 | Pride
Syntrophs Lysine acetylation 2d-page Lysine acylation Lc-ms/ms 
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