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TranscriptomicsExpression data of two human cancer cell lines cultivated in 2-dimensional (2D) vs. 3-dimensional (3D) cell culture
3D cultivation of cells lead to changes in morphology of the cells. This is likely to explain the higher radioresistance of cells growing in 3D compared to cells growing in 2D cell culture. Whole genome gene expression is performed to determine genes involved in changes of cell moroholgy and radiore...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-17347 | biostudies-arrayexpress
MetabolomicsStudy on Wax Secretion and Wax-secreting System of Mulberry Pest Paurocephala sauteri Enderlein (Hemiptera: Psyllidae).
Paurocephala sauteri Enderlein, one of the most important pests of mulberry trees in the tropical and subtropical regions, the nymphs and adults of this species penetrate the veins on the back of leaves and buds of mulberry trees, nymph and female adult can secrete wax, these wax accumulated on the ...
2024-11-04 | MTBLS11229 | MetaboLights
TranscriptomicsGene expression in a three-dimensionally cultivated human hepatocellular carcinoma (HCC) model
The development of more complex but reliable systems for compound testing in a pharmaceutical context is a challenging task to date. Three-dimensional (3D), organ mimetic cell culture is aiming to become an alternative to common two-dimensional (2D) cell culture or animal testing in that field. We d...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-41962 | biostudies-arrayexpress
TranscriptomicsGene expression in a three dimensionally cultivated human hepatocytes
The development of more complex but reliable systems for compound testing in a pharmaceutical context is a challenging task to date. Three dimensional (3D), organ mimetic cell culture is aiming to become an alternative to common two dimensional (2D) cell culture or animal testing in that field. We d...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-44580 | biostudies-arrayexpress
Transcriptomics3D cultivation of NSCLC cell lines alters gene expression of key cancer-associated signalling pathways
Background: The main focus of the work was the evaluation of gene expression differences between our established NSCLC 3D cell culture model and the 2D cell culture in regard to the use of our model for drug screening applications. Methods: The non-small cell lung cancer (NSCLC) cell lines Colo699 a...
ORGANISM(S): Homo sapiens 
2018-02-07 | GSE78210 | GEO
ProteomicsDevelopment of a 3D in vitro model of Dupuytren’s disease as a platform for drug screening
Background: Dupuytren’s disease (DD) is a common fibrotic disorder of the hand, characterized by progressive thickening and contracture of the palmar and digital fascia. Surgical excision remains the primary treatment; however, there are currently no therapies to prevent disease progression or recur...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD072354 | Pride
Myofibroblasts Proteomics Dupuytren’s disease 3d in vitro model Fibrosis Minoxidil Collagen type i Decellularization 
TranscriptomicsRNA-seq of human cancer cell lines HCT116, T47D and A549 in 3D collagen I microenvironments compared to 2D cell culture
The behavior of cancer cells strongly relies on the properties of the extracellular microenvironment. The aim was to compare the whole transcriptome of three non-invasive cancer cell lines, HCT-116, A549 and T-47D, embedded in collagen I matrices in a time-dependent manner to standard two-dimensiona...
ORGANISM(S): Homo sapiens 
2026-07-31 | E-MTAB-16838 | biostudies-arrayexpress
Unknown3D Spheroid Cultivation Alters the Extent and Progression of Osteogenic Differentiation of Mesenchymal Stem/Stromal Cells Compared to 2D Cultivation.
Not available
S-EPMC10135665 | biostudies-literature
UnknownCultureLED: A 3D printer-based LED illumination cultivation system for multi-well culture plates.
Not available
S-EPMC9194848 | biostudies-literature
Unknown3D-Printed Microfluidic Perfusion System for Parallel Monitoring of Hydrogel-Embedded Cell Cultures.
Not available
S-EPMC10378615 | biostudies-literature
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