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ProteomicsExtracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems
Background: Newer 3D culturing approaches are a promising way to better mimic the in vivo tumor microenvironment and to study the interactions between the heterogeneous cell populations of glioblastoma multiforme. Like many other tumors, glioblastoma uses extracellular vesicles as an intercellular c...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047328 | Pride
Ev Extracellular vesicle Proteomics Microrna 3d organoid model Brain cancer Glioblastoma multiforme 
TranscriptomicsAnalysis of human healthy enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent Doxorubicin (DOX) sampled at four doses (1,10, 30 and 60uM) and three time points (24, 48 and 72h).
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11297 | biostudies-arrayexpress
TranscriptomicsRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the expression characteristics of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to the medium t...
ORGANISM(S): Mus musculus 
2020-12-31 | E-MTAB-8834 | biostudies-arrayexpress
ProteomicsMimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model
Patient derived organoids (PDOs) have been established as a 3D culture model which closely recapitulates the in vivo tumor biology. However, one limitation of this culture model is the lack of tumor microenvironment which has a significant role in tumor progression and drug response. To address this...
ORGANISM(S): Homo sapiens (Human) 
2023-03-14 | PXD032047 | Pride
Cancer associated fibroblast Normal fibroblast Colorectal cancer 
GenomicsEnzymatic Methyl-seq (EM-seq) of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the genome wide DNA methylation landscape of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to t...
ORGANISM(S): Mus musculus 
2021-10-03 | E-MTAB-10979 | biostudies-arrayexpress
GenomicsCardiac organoid model of human myocardial infarction
Cardiac organoid model of human myocardial infarction
PRJNA454314 | ENA
TranscriptomicsTranscriptomics analysis of different porcine intestinal models (piglet jejunums, jejunum crypts, and organoids) and conventional cell line models upon infection with the transmissible gastroenteritis virus (TGEV)
The objective is to study the relevance of porcine intestinal models (incl. piglet jejunums, 2D and 3D organoids derived from piglet jejunums and swine testicular cells) to study intestinal functions and to decipher the host-virus interactions during viral porcine coronavirus infection. This dataset...
ORGANISM(S): Sus scrofa 
2025-10-10 | E-MTAB-15113 | biostudies-arrayexpress
UnknownEstablishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study.
Not available
S-EPMC12138948 | biostudies-literature
GenomicsCardiac organoid model of human myocardial infarction (batch2)
Cardiac organoid model of human myocardial infarction (batch2)
PRJNA473541 | ENA
UnknownEvaluation of B7-H3 Targeted Immunotherapy in a 3D Organoid Model of Craniopharyngioma.
Not available
S-EPMC9775874 | biostudies-literature
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