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MetabolomicsLipidomic Comparison of 2D and 3D Colon Cancer Cell Culture Models
Not available
ORGANISM(S): Homo sapiens 
ST002070 | MetabolomicsWorkbench
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
ProteomicsLabel-free quantification of 3D MCF10A cell culture proteome (DIA)
Global shotgun proteomic analysis using data independent acquisition (DIA) and Spectronaut analysis on the input cell lysates before the enrichment step in proximity labeling experiments, specifically MCF10A cells stably expressing miniTurbo-BAD in 3D with biotin treatment (n=4)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-21 | MSV000094825 | MassIVE
ProteomicsBAD BioID in 2D MCF10A cell culture
BioID proximity labeling experiment on Bcl2-associated agonist of cell death (BAD) using BAD-miniTurbo stable cell line in MCF10A, 2D cell culture. Sample: BAD-turbo-biotin; controls: BAD-biotin, turbo-biotin, BAD-turbo (n=3).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-10 | MSV000093357 | MassIVE
TranscriptomicsExpression data of two human cancer cell lines cultivated in 2-dimensional (2D) vs. 3-dimensional (3D) cell culture
3D cultivation of cells lead to changes in morphology of the cells. This is likely to explain the higher radioresistance of cells growing in 3D compared to cells growing in 2D cell culture. Whole genome gene expression is performed to determine genes involved in changes of cell moroholgy and radiore...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-17347 | biostudies-arrayexpress
ProteomicsA comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study C4PR_LIV
Background Three-dimensional (3D) bioengineered models of human skeletal muscle are a promising approach for studying muscle development, function and disease in vitro. These models more closely resemble the complexity of native muscle tissue than two-dimensional (2D) monolayer culture and allow for...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD061227 | Pride
Bioengineering In vitro models Skeletal muscle Maturation Proteomics 3d culture Hydrogel 
TranscriptomicsRNA-seq of human cancer cell lines HCT116, T47D and A549 in 3D collagen I microenvironments compared to 2D cell culture
The behavior of cancer cells strongly relies on the properties of the extracellular microenvironment. The aim was to compare the whole transcriptome of three non-invasive cancer cell lines, HCT-116, A549 and T-47D, embedded in collagen I matrices in a time-dependent manner to standard two-dimensiona...
ORGANISM(S): Homo sapiens 
2026-07-31 | E-MTAB-16838 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
A comparison of gene expression profiles for 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
ORGANISM(S): Homo sapiens 
2007-05-02 | E-TABM-244 | biostudies-arrayexpress
ProteomicsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffoldsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds
Hematopoietic stem cell transplantation (HSCT) is successfully applied since the late 1950s, however, its efficacy still needs to be improved. A promising strategy is to transplant high numbers of pluripotent hematopoietic stem cells (HSCs). Therefore, an advanced ex vivo culture system is needed th...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD025849 | Pride
Hematopoietic stem cell transplantation (hsct) Proteomics Foxo Cholesterol Human hematopoietic stem cell (hsc) Srebp Biomimetic In vitro amplification 3d cell cultivation system Mtor Cell metabolism 
GenomicsExpression data for 3D versus 2D cell culture
Expression data for 3D versus 2D cell culture
PRJNA1183397 | ENA
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