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MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
ProteomicsiTRAQ-Based Quantitative Proteomic Comparison of 2D and 3D Adipocyte Cell Models Co-cultured with Macrophages Using Online 2D-nanoLC-ESI-MS/MS
The demand for novel three-dimensional (3D) cell culture models of adipose tissue has been increasing, and proteomic investigations are important for determining the underlying causes of obesity, type II diabetes, and metabolic disorders. In this study, we performed global quantitative proteomic pro...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD014437 | Pride
3d-culture Macrophages Adipocytes Proteomic quantification Itraq 
TranscriptomicsTranscription profiling by array of human stromal cells cultured with or without 3D BPH-1 prostate epithelial cells
BPH-1 prostate epithelial cells when cultured in Matrigel form 3D acini which closely recapitulate the tissue architecture of the prostate. The presence of primary stroma increases epithelial adhesions and causes changes in morphology. To identify the stromal signals which control actin/cadherin dy...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-MEXP-2657 | biostudies-arrayexpress
GenomicsMicroarray of 3D cultured basal cells co-cultured with M2-like macrophages
Microarray of 3D cultured basal cells co-cultured with M2-like macrophages
PRJNA865447 | ENA
MetabolomicsBenchmark datasets for 3D MALDI- and DESI-Imaging Mass Spectrometry
Three-dimensional imaging mass spectrometry (3D imaging MS) is a technique of analytical chemistry for 3D molecular analysis of a tissue specimen, entire organ, or microbial colonies on an agar plate. 3D imaging MS has unique advantages over existing 3D imaging techniques, offers novel perspectives ...
2016-07-27 | MTBLS176 | MetaboLights
GenomicsExosomes derived from 3D-cultured hUCMSCs exhibit superior hepatoprotection against ALF
Exosomes derived from 3D-cultured hUCMSCs exhibit superior hepatoprotection against ALF
PRJNA1304384 | ENA
GenomicsExpression data from MSCs cultured on 3D and 2D matrixes
Expression data from MSCs cultured on 3D and 2D matrixes
PRJNA476593 | ENA
TranscriptomicsGene expression profiling of primary human bone marrow mesenchymal stromal cells (MSCs) cultured as 2D monolayers and 3D cellular aggregates (spheroids)
Human bone marrow mesenchymal stromal cells (MSCs) are conventionally cultured as adherent monolayers on tissue culture plastic. MSCs can also be cultured as 3D cell aggregates (spheroids). Optimised 3D conditions (60,000 MSCs cultured as a spheroid for 5 days) inhibited MSC proliferation and induce...
ORGANISM(S): Homo sapiens 
2015-09-30 | E-MTAB-3795 | biostudies-arrayexpress
TranscriptomicsHuSE2,2Dvs3D
HCV proliferation is closely related to three-dimentional cellular condition. In case of blood-borne (bb) HCV culture in HuS-E2 cells, bbHCV was reproduced only from 3D-cultured cells in hollow fibers. Thus, in order to identify novel factors which support HCV proliferation under three-dimentional c...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-MTAB-1491 | biostudies-arrayexpress
TranscriptomicsRNAseq of subcutaneous adipose tissue macrophage populations, AT-macrophages derived from 3D cultures and BM-cultured macrophages
The aim of this study was to conduct a comparative analysis between the AT-macrophages derived from 3D cultures and in vivo sc-AT macrophage populations. To this end, bulk RNA Seq analysis was performed between these two populations, and compared to BM- cultured macrophages. scAT macrophages were so...
ORGANISM(S): Mus musculus 
2024-06-24 | E-MTAB-14120 | biostudies-arrayexpress
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