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ProteomicsLC-MS/MS of SETDB1 3TD after incubation with covalent ligands
In order to confirm which amino acid of the 3TD of SETDB1 is covalently modified by a set of cysteine-targeting ligands, we performed LC-MS/MS on sample containing 40 uM of SETDB1 3TD with 400 uM of ligand after overnight incubation at 4 C.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056206 | Pride
Setdb1 Unc9846 Unc10016 Unc10013 3td Unc10014 
GenomicsSETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain
SETDB1 is a major H3K9 methyltransferase. It contains a unique Triple Tudor Domain (3TD) which specifically bind the dual modification of H3K14ac in the presence of H3K9me1/2/3. In this study, we explored the role of the 3TD H3K14ac interaction in the H3K9 methylation activity by SETDB1. We generate...
ORGANISM(S): Homo sapiens 
2024-11-15 | GSE261744 | GEO
Methylation profilingH3K14ac binding by its Triple Tudor Domain globally directs SETDB1 activity
SETDB1 is a major H3K9 methyltransferase. It contains a unique Triple Tudor Domain (3TD) which specifically bind the dual modification of H3K14ac in the presence of H3K9me1/2/3. In this study, we explored the role of the 3TD H3K14ac interaction in the methylation of H3K9 methylation activity of SETD...
ORGANISM(S): Homo sapiens 
2024-12-27 | GSE264388 | GEO
UnknownSETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain.
Not available
S-EPMC11662677 | biostudies-literature
GenomicsH3K14ac is linked to methylation of H3K9 by the Tudor domains of SETDB1
Mononucleosomes were isolated from murine ES cells and precipitated with the recombinant SETDB1 Triple Tudor Domain (3TD), recombinant SETDB1 Triple Tudor domain Y268A mutant, anti-H3K9me2 (Abcam, ab1220), or anti-H3K9me1 (Abcam, ab8896, Lot GR185298-1) antibodies.
ORGANISM(S): Mus musculus 
2018-07-30 | E-MTAB-4982 | biostudies-arrayexpress
UnknownPotent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Not available
S-EPMC11850789 | biostudies-literature
UnknownH3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Not available
S-EPMC5727127 | biostudies-literature
UnknownPrognostic significance of tumor deposit counts in stage III colorectal cancer based on T/N staging and chemotherapy status: A retrospective cohort study.
Not available
S-EPMC11908539 | biostudies-literature
GenomicsSETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain
SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain
PRJNA1088534 | ENA
UnknownThe scientific value of numerical measures of human feelings.
Not available
S-EPMC9586273 | biostudies-literature
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