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ProteomicsA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering the mechanisms underlying diseases such as cancer. To enable the in-depth analysis of protein interactions in chromatin-associated protein complexes, we have previously developed a met...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD007968 | Pride
Breast cancer Proteomics Qplex-rime Tmt 4-hydrotamoxifen Rime Clinical samples Isobaric labelling Patient derived xenografts (pdx) Estrogen receptor alpha Interactome 
GenomicsChIP-seq of old and new H3.3 in RPE1-hTERT cells
On of the H3.3 genes (H3F3B) was C-terminally tagged with a recombination-induced tag exchange (RITE) tag in human RPE1-hTERT cells to follow old (V5 tag) and new (FLAG tag) H3.3 and measure the dynamics of H3.3. New H3.3 was induced by activating Cre recombinase with 4-hydrotamoxifen (4OHT). ChIP-s...
ORGANISM(S): Homo sapiens 
2020-02-29 | GSE146120 | GEO
GenomicsChIP-seq of old and new H3.3 in RPE1-hTERT cells
ChIP-seq of old and new H3.3 in RPE1-hTERT cells
PRJNA609333 | ENA
TranscriptomicsCebpa regulates gene transcription in basophils
To investigate the mechanisms by which C/EBPa drives basophil differentiation and maintains basophil identity, we examined whether or not C/EBPa promotes basophil molecular programming and simultaneously represses mast cell molecular programming. We performed genome-wide gene expression profiling on...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-41596 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of FACS sorted – cytokine stimulated Enteric Glia cells from the LMMP after in vitro expansion
The Experiment was performed to understand the changes in expression profile of enteric glia cells in vitro to specific cytokines. Enteric glia are crucial regulators of gastrointestinal motility and immunity; however, it is not fully understood what specific cytokines can elicit a response in enter...
ORGANISM(S): Mus musculus 
2025-07-01 | E-MTAB-14879 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics of adipocyte-specific ATGL-KO mice 24 h after cardiac ischemia
We generated a tamoxifen-inducible, adipocyte-specific ATGL-KO animals to analyze the role of adipocyte ATGL in cardiac ischemia/reperfusion. KO was induced in 10 weeks old male mice via 7d of consecutive i.p.-injections of 500µg hydroxytamoxifen/day. Pnpla2-flox homozygous, Cre-negative littermates...
ORGANISM(S): Mus musculus 
2026-02-28 | E-MTAB-12700 | biostudies-arrayexpress
GenomicsChIP-seq mapping of KAT8 acetylatransferase at AsiSI-induced DNA double strand break sites
C8orf33-proficient and deficient DIvA cells were treated with 4-hydroxy tamoxifen (4OHT) to induce DNA double strand breaks (DSB) at several loci within the human genome. following 4OHT treatment cells were subject to ChIP-seq analysis for KAT8 acetyltransferase to map its enrichment at DSB sites in...
ORGANISM(S): Homo sapiens 
2025-04-10 | E-MTAB-15055 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
GenomicssnRNA Orchestrates ATM Activation to Promote Accurate Repair within Transcriptionally Active Chromatin (ChIP-seq)
Genomic integrity within transcriptionally active regions is crucial for averting oncogenic mutations, yet the precise mechanisms governing DNA double-strand break (DSB) repair in these areas remain elusive. This study reveals that the IRAK1-spliceosome axis orchestrates small nuclear RNA (snRNA) as...
ORGANISM(S): Homo sapiens 
2026-08-31 | E-MTAB-15822 | biostudies-arrayexpress
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