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ProteomicsTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions
Estrogen receptor-alpha (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER-transcriptional activity is not clear. We sought to identify the contribution of GATA3 to...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD019438 | Pride
Breast cancer Estrogen receptor alpha Tet2 Qplex-rime 
ProteomicsARID1A RIME in human cell lines and tissue xenografts.
Examination of chromatin-bound proteins associated with ARID1A, BRG1 and ERa in MCF7 cells and ERa in ER+ patient-derived xenografts using RIME protocol and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD011810 | Pride
Human Arid1a Rime Qplex 
ProteomicsA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering the mechanisms underlying diseases such as cancer. To enable the in-depth analysis of protein interactions in chromatin-associated protein complexes, we have previously developed a met...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD007968 | Pride
Breast cancer Proteomics Qplex-rime Tmt 4-hydrotamoxifen Rime Clinical samples Isobaric labelling Patient derived xenografts (pdx) Estrogen receptor alpha Interactome 
UnknownA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.
Not available
S-EPMC5998130 | biostudies-literature
UnknownDependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.
Not available
S-EPMC10147683 | biostudies-literature
ProteomicsDependency of NELF-E-KAT2B epigenetic axis in breast cancer carcinogenesis
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Here, we identified the transcriptional complex, NELF (Negative elongation factor), as an important regulator of this process. Using cancer cell lines and patient-derived tumor organoids, we demonstrated th...
ORGANISM(S): Homo Sapiens (human) 
2023-01-28 | PXD031304 | JPOST Repository
ProteomicsSWI/SNF is a gatekeeper of chromatin access at enhancer networks controlling triple-negative breast cancer progression
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with high metastatic potential, limited treatment options and low patient survival rates. By combining functional proteomics and genomics approaches, we identify an oncogenic transcriptional network in mesench...
ORGANISM(S): Homo sapiens (Human) 
2025-08-27 | PXD050921 | Pride
Lc-msms Breast cancer Human cell lines 
Methylation profilingTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions [MMS/RRHP]
Estrogen receptor-a (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER transcriptional activity is not clear. We sought to identify the contribution of GATA3 to the...
ORGANISM(S): Homo sapiens 
2021-02-10 | GSE153252 | GEO
GenomicsTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions [ChIP-Seq]
Estrogen receptor-a (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER transcriptional activity is not clear. We sought to identify the contribution of GATA3 to the...
ORGANISM(S): Homo sapiens 
2021-02-10 | GSE153251 | GEO
TranscriptomicsTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions [RNA-Seq]
Estrogen receptor-a (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER transcriptional activity is not clear. We sought to identify the contribution of GATA3 to the...
ORGANISM(S): Homo sapiens 
2021-02-10 | GSE153250 | GEO
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