Sort   by:  
 Page size 
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
ProteomicsContext Dependent Effects of Ascorbic Acid Treatment in TET2 Mutant Myeloid Neoplasia
Loss-of-function TET2 mutations (TET2MT) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2MT thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA) increases dioxygenase activity by facilitating ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD020550 | Pride
Mds Hat Therapy Ascorbic acid Lysine acetylation Prevention Tet2 Leukemia Hdac Sirtuins 
ProteomicsTET2 binding protein of human colon cancer cell SW480-SW620
This project was aimed to identify proteins interatcted with TET2 and the differences between SW480 and SW620.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD020080 | Pride
Tet2 colon cancer sw480-sw620 
TranscriptomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (Affymetrix)
DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-59586 | biostudies-arrayexpress
TranscriptomicsB-cell tumor development in Tet2-deficient mice
The TET2 gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations are also id...
ORGANISM(S): Mus musculus 
2019-12-12 | E-MTAB-8501 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (RNA-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50198 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (CMS-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50200 | biostudies-arrayexpress
TranscriptomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis [Agilent]
DNA methylation is tightly regulated throughout mammalian development and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect...
ORGANISM(S): Mus musculus 
2015-04-30 | E-GEOD-68415 | biostudies-arrayexpress
TranscriptomicsTET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (DNA methylation)
Genome wide DNA methylation profiling of patient samples with TET2 mutations and Wild type TET2 status . The Illumina Infinium HumanMethylation 450_15017482_v.1.1 was used to obtain DNA methylation profiles across approximately 482,421 CpGs in fresh frozen lymphoma samples. Samples include 19 TET2...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37362 | biostudies-arrayexpress
Proteomics14-3-3 protects AMPK phosphorylated TET2 from dephosphorylation by PP2A
Ten-eleven translocation-2 (TET2) is a member of the methylcytosine dioxygenase family of enzymes implicated in cancer and in aging due to its role as a global epigenetic modifier. TET2 has a large N-terminal domain followed by a catalytic C-terminal. Previous reports have demonstrated that the cata...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD016160 | Pride
5hmc Ampk Pp2a Tet2 Post-translational modification 14-3-3 
Sort   by:  
 Page size