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MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
ProteomicsReprogramming the Lipid Peroxidation Product 4-ONE as a Chemoselective Cleavable Crosslinker
Nature builds and stabilizes proteins through covalent biological glues, yet the logic and traceability of metabolite-driven crosslinking remain obscure. Here we reprogram the lipid peroxidation product 4-oxo-nonenal (4-ONE) into a metabolite-derived Cys-Lys biological glue and mass-cleavable crossl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077887 | Pride
4-one Peroxidation Mass spectrometry Crosslink Lipid 
ProteomicsReprogramming the Lipid Peroxidation Product 4-ONE as a Chemoselective Cleavable Crosslinker
Nature builds and stabilizes proteins through covalent biological glues, yet the logic and traceability of metabolite-driven crosslinking remain obscure. Here we reprogram the lipid peroxidation product 4-oxo-nonenal (4-ONE) into a metabolite-derived Cys-Lys biological glue and mass-cleavable crossl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077820 | Pride
4-one Peroxidation Mass spectrometry Crosslink Lipid 
Proteomics4-ONE as a Chemoselective Biological Glue for Site-Resolved Protein Crosslinking and Proteomic Profiling
Protein crosslinking governs structure, stability, and interaction networks in biology, yet current chemical crosslinkers lack selectivity, produce heterogeneous products, and require pre-installed cleavable handles for analysis. Here, we report a conceptually distinct strategy that harnesses the in...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD070252 | Pride
ProteomicsIncreased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis
The cytochrome P450 limonene-6-hydroxylase (P450), cytochrome P450 reductase (CPR) and carveol dehydrogenase (CDH) were expressed in Escherichia coli for (−)-carvone production from (−)-limonene. The optimum ratio of enzyme expression to maximize (−)-carvone production was determined using the prote...
ORGANISM(S): Escherichia Coli 
2022-08-24 | PXD028077 | JPOST Repository
GenomicsEffect of cardiac specific depletion of one allele of Mrps5 on gene expression in heart at postnatal day 4
Effect of cardiac specific depletion of one allele of Mrps5 on gene expression in heart at postnatal day 4
PRJNA827591 | ENA
ProteomicsXanthohumol Activity-Based Probes Targeting Flavonoid Catabolism
Xanthohumol, the principle prenylflavonoid found in hops (Humulus lupulus), is a potential anti-inflammatory agent in the gut. To investigate the interactions between xanthohumol and catabolic gut bacteria, and its role in the anti-inflammatory pathway, a suite of xanthohumol-derived activity-based ...
ORGANISM(S): Eubacterium Ramulus (ncbitaxon:39490) Escherichia Coli (ncbitaxon:562) 
2022-02-04 | MSV000088789 | MassIVE
GenomicsOne-pot universal NicE-seq: All enzymatic downstream processing of 4% formaldehyde crosslinked cells for chromatin accessibility genomics
One-pot universal NicE-seq: All enzymatic downstream processing of 4% formaldehyde crosslinked cells for chromatin accessibility genomics
PRJNA733150 | ENA
GenomicsRNA-sequence analysis of Burkholderia vietnamiensis strain G4 exposed to ethylzingerone 4-(3-ethoxy-4-hydroxyphenyl) butan-2-one)
RNA-sequence analysis of Burkholderia vietnamiensis strain G4 exposed to ethylzingerone 4-(3-ethoxy-4-hydroxyphenyl) butan-2-one)
PRJEB32295 | ENA
TranscriptomicsExpression data from one year old leaves of Populus simonii by chilling stress (4°C, 10h).
We take the one year old plant for chilling stress (4°C, 10h) and controls.Use the Affymetrix poplar gene chip to decrypt the gene functions and mechanisms in Populus simonii leaves. We used microarrays to detail the global programme of gene expression during chilling stress (4°C, 10h).
ORGANISM(S): Populus sp. Populus simonii 
2014-05-16 | GSE43872 | GEO
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