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Left ventricular hypertrophy (LVH) is critical in chronic kidney disease (CKD), but its mechanisms remain unclear. This study employed multi-omics approaches, including RNA-seq and integrated metabolomics, to characterize metabolic alterations in cardiomyocytes (CM) of CKD mice, revealing enhanced g...
ORGANISM(S): Homo sapiens (Human) 
2026-09-30 | PXD077955 | Pride
This project carried out a quantitative study of lactylation in HMC3 Cell Line. In order to ensure a high degree of credibility of the results, we used the standard of localization probability>0.75 to filter the authentication data. In this study, a total of 3093 lactylation sites located on 1270 pr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-28 | PXD028737 | Pride
Colitis-associated colorectal cancer (CAC), a subtype of colorectal cancer arising from chronic colonic inflammation, remains without specific therapeutic agents. Banxia-Xiexin decoction (BXD), a traditional Chinese medicine, is clinically used to treat gastritis and ulcerative colitis; however, its...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD065556 | Pride
Membrane vesicles (MVs) are produced by species across all domains of life and have diverse physiological functions and promising applications. While the mechanisms for vesiculation in Gram-negative bacteria are well-established, the genetic determinant and regulation of MVs biogenesis in Gram-posit...
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2024-01-10 | PXD048184 | Pride
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