Sort   by:  
 Page size 
MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
MetabolomicsGlutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer
Not available
ORGANISM(S): Mus musculus 
ST002066 | MetabolomicsWorkbench
ProteomicsGlutaminase C N-terminus phosphorylation decreases its enzymatic activity
The gene GLS generates the phosphate activated glutaminase C (GAC) isoform by alternative splicing. GAC, compared to the other isoform, kidney-type glutaminase (KGA), has been characterized as more active and particularly important for cancer cell growth. Very little is known about post-translationa...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD008338 | Pride
Metabolism Mapk1 Breast cancer Glutaminase Phosphorylation 
MetabolomicsEvidence that class I glutamine amidotransferase, GAT1_2.1, acts as a glutaminase in roots of Arabidopsis thaliana
Not available
ORGANISM(S): Arabidopsis thaliana 
ST001811 | MetabolomicsWorkbench
MetabolomicsEvidence that class I glutamine amidotransferase, GAT1_2.1, acts as a glutaminase in roots of Arabidopsis thaliana (part II)
Not available
ORGANISM(S): Arabidopsis thaliana 
ST001812 | MetabolomicsWorkbench
TranscriptomicsDifferential Regulation of Th17 and Th1 Cells in mouse by Glutaminase-Dependent Metabolism and Chromatin Remodeling
Activated T cells differentiate into functional subsets which require distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to provide substrate for the tricarboxylic acid cycle and epigenetic reactions and here we identify a key role for GLS in T cell activation and specifi...
ORGANISM(S): Mus musculus 
2018-09-01 | E-MTAB-6648 | biostudies-arrayexpress
GenomicsLoss of mammalian glutaminase orthologs impairs sperm function in C. elegans
Loss of mammalian glutaminase orthologs impairs sperm function in C. elegans
PRJNA929928 | ENA
TranscriptomicsLoss of mammalian glutaminase orthologs impairs sperm function in C. elegans
The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as neurotransmission, metabolism, and cellular senescence. Here we repo...
ORGANISM(S): Caenorhabditis elegans 
2023-02-15 | GSE224117 | GEO
GenomicsEndogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib
Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib
PRJNA1187621 | ENA
TranscriptomicsSystematic design and functional analysis of artificial microRNAs as an approach for multi-gene targeting
Unlike short interfering RNAs (siRNAs), which are commonly designed to repress a single messenger RNA (mRNA) target through perfect base pairing, microRNAs (miRNAs) are endogenous small RNAs that have evolved to concurrently repress multiple mRNA targets through imperfect complementarity. MicroRNA t...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50249 | biostudies-arrayexpress
Sort   by:  
 Page size