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TranscriptomicsAnalysis of ETS gene expression patterns uncovers novel ETS mediated gene silencing pathways in prostate cancers
Deregulated expression of ETS transcription factors with oncogenic and tumor suppressor function occurs frequently in prostate cancer leading to profound alterations of the cancer transcriptome. By integrating genomic and functional studies we identified key targets of the aberrantly expressed ETS ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-14206 | biostudies-arrayexpress
GenomicsOncogenic ETS proteins replace activated Ras/MAPK signaling in prostate cells.
Approximately 50% of prostate cancers have chromosomal translocations resulting in the over-expression one of four ETS family transcription factors. However, it is not known why these four four family members are selected for oncogenic roles, while other ETS proteins are not. We found that the four...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-29808 | biostudies-arrayexpress
GenomicsGenome-wide analysis of ETS factor ER71/ETV2 chromatin occupancy
We discover that ER71/ETV2 initiates hemangiogenic program by activating blood and endothelial cell lineage specifying genes while enhancing FLK1 expression and expanding hemangioblast population. Furthermore, ER71/ETV2 establishes an ETS hierarchy by directly activating Ets genes in hematopoietic a...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-59402 | biostudies-arrayexpress
TranscriptomicsOncogenic ETS proteins regulate a Ras/MAPK gene expression program in the absence of MAPK signaling
Approximately 50% of prostate cancers have chromosomal translocations resulting in the over-expression one of four ETS family transcription factors. However, it is not known why these four four family members are selected for oncogenic roles, while other ETS proteins are not. We found that the four...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-29438 | biostudies-arrayexpress
TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
GenomicsChIP-seq of wild type and ets-5-gfp worms
ChIP-seq of wild type and ets-5-gfp worms
PRJNA680269 | ENA
GenomicsEts homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [ChIP-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF c...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-63398 | biostudies-arrayexpress
GenomicsmRNAseq of wild type and ets-5 mutant C. elegans BAG neurons
mRNAseq of wild type and ets-5 mutant C. elegans BAG neurons
PRJNA680272 | ENA
TranscriptomicsEts homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [RNA-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF c...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-63397 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of primary prostate cancer biopsies wutg different ETS transcription factor rearrangements
This work was conducted to identify shared and specific target genes of different ETS transcription factor rearrangements in prostate cancer. Potential target genes were identified by differential gene expression analysis of primary tumor samples with ETS rearrangements, and validated by ETS silenci...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-42954 | biostudies-arrayexpress
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