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Transcriptomics5-aza-2-deoxycytidine treatment of Swarm rat chondrosarcoma cells
The puropose of this experiment was to identify gene expression changes that result from 5-aza-2-deoxycytidine induced DNA demethylation of Swarm rat chondrosarcoma cells. The gene expression profiles of untreated Swarm rat chondrosarcoma cells were compared to the gene expression profiles of Swarm...
ORGANISM(S): Rattus norvegicus 
2010-08-06 | E-GEOD-17598 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of three human multiple myeloma cell lines treated with 5-aza-2-deoxycytidine and/or trichostatin A
To identify epigenetically silenced genes in multiple myeloma (MM) cell lines and to determine the effects of 5-aza-2-deoxycytidine and trichostatin A on gene expression. We treated 3 multiple myeloma cell lines (MM1, NCI-H929, U266) with 5-aza-2-deoxycytidine and/or trichostatin A.
ORGANISM(S): Homo sapiens 
2008-02-01 | E-MEXP-1269 | biostudies-arrayexpress
ProteomicsSUMO pulldown proteomics Namalwa 5-Aza-2' deoxycytidine treatment
Combination therapies targeting malignancies aim to increase treatment efficacy and reduce toxicity. Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’) enhances transcription of tumor suppressor genes and induces replication errors via entrapment of DNMT1. Post-translational modification by SUMO...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD038620 | Pride
5-aza-2' deoxycytidine B cell lymphoma Sumoylation 
ProteomicsSUMO pulldown, U2OS, proteomics, 4 hour 20 hour 5-Aza-2' deoxycytidine treatment
Combination therapies targeting malignancies aim to increase treatment efficacy and reduce toxicity. Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’) enhances transcription of tumor suppressor genes and induces replication errors via entrapment of DNMT1. Post-translational modification by SUMO...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD038617 | Pride
5-aza-2' deoxycytidine B cell lymphoma Sumoylation 
TranscriptomicsMicroRNA profiling of human cancer cells after treatment with the chromatin modifying drugs 5-aza-2 deoxycytidine and 4-phenylbutyric acid
miRNA expression profiling in human cancer cells after 5-aza-2'-deoxycytidine and 4-phenylbutyric acid treatment to investigate whether microRNA expression is controlled by these chromatin modifying drugs.
ORGANISM(S): Homo sapiens 
2005-01-01 | E-MEXP-706 | biostudies-arrayexpress
TranscriptomicsMCF7 cells gene expression change by inducing CpG demethylation using 5-Aza-2'-deoxycytidine (Aza)
Promoter methylation is able to induce downregulation of gene expression. 5-Aza-2'-deoxycytidine(Aza), methytransferase inhibitor, induce CpG demethylation. Here, 5-Aza-2'-deoxycytidine(Aza) is treated in a human breast cancer cell, MCF7, for detection of gene expression change. To analyze gene expr...
ORGANISM(S): Homo sapiens 
2011-08-17 | E-GEOD-31441 | biostudies-arrayexpress
Transcriptomics(CTA) expression after exposure to 5-aza-2'-deoxycytidine in HCT116 cells
The expression of CTAs is normally restricted to gametogenic tissue but is often reactivated in the tumorigenic setting. This tumorigenic reactivation is thought to be due to global demethylation events during tumorigenesis. To test this, we employed an affymetrix microarray in the hypermethylated c...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-79041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary dermal fibroblasts treated with DNA demethylating agent 5-aza-2-deoxycytidine and sorted by X-chromosome-linked GFP expression
Primary mouse dermal fibroblasts from heterozygous female X chromosome-linked GFP mice were sorted through FACS for GFP non-expressing cells (~50% of cells due to X-inactivation). The GFP- cells were treated with 4uM 5-aza-2'-deoxycytidine (5A2dC) for 48 hours with recovery in normal medium for 24 ...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-704 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary dermal fibroblasts treated with DNA demethylating agent 5-aza-2-deoxycytidine
Mouse primary dermal fibroblasts were treated with DNA demethylating agent 5-aza-2'-deoxycytidine. The exposure was 5um 5A2dC for 96 hours followed by recovery in normal medium for 24 hours. Three biological replicates were created for both the control and treated populations. Each biological rep...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-701 | biostudies-arrayexpress
GenomicsGenome-wide DNA demethylation of TGW (neuroblastoma cell line) after treatment of mock and 5-aza-2'-deoxycytidine (5-aza-dC)
Genome-wide DNA demethylation of TGW (neuroblastoma cell line) after treatment of mock and 5-aza-2'-deoxycytidine (5-aza-dC)
PRJNA749038 | ENA
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