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ProteomicsIdentification of novel 53BP1 associated proteins
We used homologous recombination based CRISPR Knock-in strategy to insert a SFB tag at C terminal of 53BP1 in 293T cells. We performed tandem affinity purification of endogenous 53BP1 in both soluble and chromatin fraction to uncover known and new 53BP1 binding proteins which might play roles in DNA...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020090 | Pride
53bp1 
TranscriptomicsTranscription profiling by array of chicken wild type and tumor supressor 53Bp1 knockout lymphoblast cells
Effect of abrogation of the tumour supressor 53Bp1 on gene expression in the chicken DT40 model system
ORGANISM(S): Gallus gallus 
2011-05-07 | E-MEXP-2721 | biostudies-arrayexpress
GenomicsMus musculus strain:53BP1-/- MycI/I AID-/-
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma
PRJNA179363 | ENA
ProteomicsThe dimeric deubiquitinase Usp28 integrates 53bp1 and Myc functions to limit DNA damage
The oncogenic transcription factor Myc is a pleiotropic regulator of RNA Polymerase II (RNAPII)-dependent transcription, DNA replication and DNA damage response pathways. Myc is stringently regulated by the ubiquitin system - for example, ubiquitination controls recruitment of the elongation factor ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-09 | PXD037263 | Pride
Human Ap-ms Immunoprecipitation Usp28 53bp1 
Genomics53BP1 genomic binding
53BP1 binding analysis in HeLa cells
PRJEB12222 | ENA
TranscriptomicsNext Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes
Absence of 53BP1 influences the profile of DNA rearrangements in B lymphocytes.To determine whether the differences in translocation partner choice were due to differences in transcription, we compared the transcriptome of 53BP1 deficient and wild-type B cells by RNA-Seq and Polymerase II chromatin ...
ORGANISM(S): Mus musculus 
2013-02-12 | E-GEOD-42350 | biostudies-arrayexpress
ProteomicsGFI1 facilitates efficient DNA repair by regulating PRMT1-dependent methylation of MRE11 and 53BP1
GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GF...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008897 | Pride
Dna repair gfi1 prmt1 methylation mre11 53bp1 
Genomics53BP1 condensate regulates the completion of heterochromatin DNA replication
53BP1 condensate regulates the completion of heterochromatin DNA replication
PRJNA1332779 | ENA
TranscriptomicsA damage independent role for 53BP1 that impacts break order and Igh architecture during CSR
During Class Switch Recombination (CSR) B cells replace the Igh Cμ/δ exons with another downstream constant region exon (CH), altering the antibody isotype. CSR occurs through the introduction of AID-mediated double strand break (DSBs) in switch regions and subsequent ligation of broken ends. Here...
ORGANISM(S): Mus musculus 
2016-06-16 | E-GEOD-81180 | biostudies-arrayexpress
GenomicsShort Title: 53bp1 supports p53-family transcriptional program
Short Title: 53bp1 supports p53-family transcriptional program
PRJNA1498127 | ENA
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