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TranscriptomicsDual regulation of Fbw7 function and oncogenic transformation by Usp28
Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-mediated substrate degradation is antagonized by the Usp28 deubiquitinase. We now show, using knockout mice, that Usp28 preferentially deubiq...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-59354 | biostudies-arrayexpress
ProteomicsThe dimeric deubiquitinase Usp28 integrates 53bp1 and Myc functions to limit DNA damage
The oncogenic transcription factor Myc is a pleiotropic regulator of RNA Polymerase II (RNAPII)-dependent transcription, DNA replication and DNA damage response pathways. Myc is stringently regulated by the ubiquitin system - for example, ubiquitination controls recruitment of the elongation factor ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-09 | PXD037263 | Pride
Human Ap-ms Immunoprecipitation Usp28 53bp1 
GenomicsEffect of Usp28 knockout and re-consitution of wildtype or monomeric Usp28 on gene expression in hepatocellular carcinoma cells
Effect of Usp28 knockout and re-consitution of wildtype or monomeric Usp28 on gene expression in hepatocellular carcinoma cells
PRJNA882860 | ENA
ProteomicsUSP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
Oncogenic transformation of lung epithelial cells is a multi-step process, frequently starting with the inactivation of tumor suppressors and subsequent activating mutations in proto-oncogenes, such as members of the PI3K or MAPK family. Cells undergoing transformation have to adjust to changes, suc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD032810 | Pride
Braf Buparlisib C-jun Vemurafenib Usp28 Lung cancer Egfr Pik3ca C-myc Hras gefitinib 
GenomicsImpact of USP28 monoallelic deletion in HG3 CLL-derived cells
Impact of USP28 monoallelic deletion in HG3 CLL-derived cells
PRJNA955786 | ENA
TranscriptomicsEffect of Usp28 knockout and re-consitution of wildtype or monomeric Usp28 on gene expression in hepatocellular carcinoma cells
Usp28-KO HLF cell lines were generated by CRISPR-Cas9. Usp28-KO cells expressing Usp28-WT, Usp28-Mono or a control vector were established by lentiviral transduction.
ORGANISM(S): Homo sapiens 
2023-09-30 | GSE213892 | GEO
TranscriptomicsTranscription profiling of human carcinoma LS174T cells following depletion of Myc and Usp28 using shRNA
Analysis of gene expression following depletion of Myc and Usp28 using shRNA in colon carcinoma LS174T cells.
ORGANISM(S): Homo sapiens 
2007-04-19 | E-MEXP-1070 | biostudies-arrayexpress
ProteomicsUSP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient 5-year survival rate is less than 5%. The ubiquitin specific protease 28 (USP28) has been implicated in tumorigenesis through its s...
ORGANISM(S): Homo sapiens (Human) 
2024-07-30 | PXD023339 | Pride
Abpp Usp28 Lung squamous cell carcinoma (lscc) 
TranscriptomicsDual regulation of Fbw7 function and oncogenic transformation by Usp28
Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-mediated substrate degradation is antagonized by the Usp28 deubiquitinase. We now show, using knockout mice, that Usp28 preferentially deubiq...
ORGANISM(S): Mus musculus 
2015-05-01 | GSE59354 | GEO
GenomicsInhibition of USP28 sensitizes ovarian cancer to PARP inhibitor through mediating SOX9 deubiquitination
Inhibition of USP28 sensitizes ovarian cancer to PARP inhibitor through mediating SOX9 deubiquitination
PRJNA1130878 | ENA
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