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ProteomicsProteomic analyses of embryogenic tissues in Picea balfouriana treated by 6-BAP
In this study, iTRAQ technology was applied to characterize the genes and proteins that are differentially expressed among tissues under the influence of different levels of 6-BAP(2.5 μM, 3.6 μM and 5 μM). There were two biological and three technological replicates for each treatment. Two biologica...
ORGANISM(S): Picea likiangensis var. rubescens 
2014-09-23 | PXD001022 | Pride
Picea balfouriana 6-bap Embryogenic tissues Lc-ms/ms 
Transcriptomicsribo-depleted RNA-Seq of human HepG2 cells exposed to Benzo[a]pyrene for 6, 12, 18, 24, 36 and 48 hours
HepG2 cells (human liver hepatocarcinoma) were exposed for 6 different time points (6,12,18,24,36 and 48h) to Benzo[a]pyrene (BaP) in duplicate. Total RNAs were ribo-depleted and sequenced on an Illumina Hiseq2000 in pair-end 100 bp reads. One of the duplicates for BaP-treated sample at the 24 hour ...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-MTAB-3292 | biostudies-arrayexpress
UnknownChanges in the Metabolome of Picea balfouriana Embryogenic Tissues That Were Linked to Different Levels of 6-BAP by Gas Chromatography-Mass Spectrometry Approach.
Not available
S-EPMC4627733 | biostudies-literature
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-58782 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling in adult mouse liver following benzo(a)pyrene (BaP) treatment [Exiqon miRNA array]
Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene (BaP), as detected using Exiqon miRNA arrays. Adult male mice were exposed to 150 mg/kg benzo(a)pyrene (BaP) or solvent for 3 days and sampled 4 hours after the last dose. MicroRNA expression levels in...
ORGANISM(S): Mus musculus 
2010-10-18 | E-GEOD-18782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Medicago truncatula 2HA and Jemmalong during somatic embryogenesis
The Medicago truncatula line 2HA has a 500-fold greater capacity to regenerate plants in culture by somatic embryogenesis than wild-type Jemalong. We have compared transcriptomes of tissue cultures from leaf explants of these two lines. We have used the Affymetrix Medicago Genome Array GeneChip to c...
ORGANISM(S): Medicago truncatula 
2008-06-16 | E-GEOD-8131 | biostudies-arrayexpress
TranscriptomicsBenzo[a]pyrene-induced changes in microRNA-mRNA networks
The microarray contains 9360 reporters, each present four times on the microarray. In our analysis 1326 human and viral reporters were used, of which 880 are unique human mature microRNAs. The other 8024 reporters represent microRNAs from other species. cDNA was generated using 1 M-NM-
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-31252 | biostudies-arrayexpress
ProteomicsA study on degradation efficiency of fluoranthene and membrane protein mechanism of Rhodococcus sp. BAP-1 based on iTRAQ
Comparative proteomic analysis was operated on membrane proteins extracted from fluoranthene-exposed cells on 1, 3 and 6 d compared to control cells using proteomics to access differentially expressed proteins. The results showed that Rhodococcus sp. BAP-1 had good degradation ability on the first a...
ORGANISM(S): Rhodococcus Baikonurensis 
2019-09-19 | PXD015501 |
TranscriptomicsTranscription profiling of human lung adenocarcinoma A549 cells treated with vehicle (DMSO) or Etoposide (ETOP, 10 uM ), Benzo(a)pyrene Cryptolepineand 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine for 6 h, 16 h, 24 h, 48 h and 72 h
Title: Prediction of cell cycle behaviour in response to DNA damage agents via transcriptomic approach
Description: Human lung adenocarcinoma A549 cells were treated with vehicle (DMSO) or Etoposide (ETOP, 10 M-BM-5M ), Benzo(a)pyrene (BaP, 25 M-BM-5M ), Cryptolepine ( CLP, 2.5 M-BM-5M) and 2...
ORGANISM(S): Homo sapiens 
2006-06-01 | E-MIMR-102 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP 8hr]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51173 | biostudies-arrayexpress
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