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MetabolomicsStudy on root metabolism of cassava TRV-MeCOMT8

This project is based on non targeted metabolomics analysis of cassava (Manihot esculenta) root samples. LC-MS/MS is used to obtain metabolite characteristic peaks and perform peak extraction, alignment, and quantification. Differential metabolites are screened, with a focus on flavonoid and phen...

2026-05-06 | MTBLS14086 | MetaboLights
MetabolomicsLily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
MetabolomicsFlavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling

Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. While these metabolites protect against light damage, their roles in modulating photoreceptor responses remain unclear. Here we show that naringenin chalcone (N...

2025-07-30 | MTBLS12792 | MetaboLights
MetabolomicsCoordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
2016-10-03 | MTBLS129 | MetaboLights
MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
MetabolomicsAn overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in senescence-accelerated mouse prone-8 mice
Nucleotides (NTs) are regulatory factors in many biological processes and play important roles in the growth, development, and metabolism of living organisms. We used senescence-accelerated mouse prone-8 (SAMP8) to investigate the effects of NTs on the gut microbiota and metabolites. And the promoti...
2022-03-21 | MTBLS4012 | MetaboLights
MetabolomicsUBXD8 lipidomics from whole cells (Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST002422 | MetabolomicsWorkbench
MetabolomicsMicrobiota Reprogramming Driven by 7,8-Dihydroxyflavone Potentiates Xanthine Oxidase to Mitigate Hyperuricemia
Hyperuricemia (HUA), primarily driven by xanthine oxidase (XO)-mediated uric acid production, presents substantial challenges to both human health and livestock productivity. While conventional XO inhibitors are effective in mitigating HUA, they are often linked to severe adverse effects. In this st...
2026-04-29 | MTBLS14398 | MetaboLights
MetabolomicsNon-targeted metabolomic profiling reveals Flo8-associated metabolic alterations in Candida glabrata
Flo8 is a transcriptional regulator involved in multiple physiological processes in Candida glabrata. To investigate the metabolic changes associated with Flo8, non-targeted metabolomic profiling was performed using the reference strain and a FLO8 deletion mutant. Intracellular metabolites were extr...
2026-08-19 | MTBLS15156 | MetaboLights
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