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TranscriptomicsRedefining the translational status of 80S monosomes
Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the former has been studied extensively, to what extent translation occurs on monosomes and its importance for overall translational output remains controversial. Here, we used ribosome profiling to examine the transl...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-11 | E-GEOD-76117 | biostudies-arrayexpress
UnknownMammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.
Not available
S-EPMC6373978 | biostudies-literature
GenomicsHead and Embryo 80S monosomes are much more translationally active than 80S in other tissues
Head and Embryo 80S monosomes are much more translationally active than 80S in other tissues
PRJNA1111495 | ENA
TranscriptomicsHead and Embryo 80S monosomes are much more translationally active than 80S in other tissues
Translational regulation at the stage of initiation impacts the number of ribosomes translating each mRNA molecule. For example, multiple ribosomes can engage on a single mRNA forming a polysome, resulting in highly efficient protein synthesis. However, the translational activity of single 80S ribos...
ORGANISM(S): Drosophila melanogaster 
2025-03-24 | GSE267425 | GEO
TranscriptomicsRedefining the translational status of 80S monosomes
Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the former has been studied extensively, to what extent translation occurs on monosomes and its importance for overall translational output remains controversial. Here, we used ribosome profiling to examine the transl...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-11 | GSE76117 | GEO
GenomicsSaccharomyces cerevisiae
Redefining the translational status of 80S monosomes
PRJNA306259 | ENA
ProteomicsZNF692 organizes a hub for ribosome maturation enhancing translation in rapidly proliferating cells
Human cancer cell lines (DLD1 wt or ZNF692 KO, and for IP-proteomics HCT116 transfected with GFP, GFP-ZNF692 and deltaNolsZNF692). 788570, HCT116 transfected with GFP; 788571, HCT116 transfected with GFP-ZNF692; 788572, HCT116 transfected with deltaNolsZNF692; 937612, control 40S subunit from DLD1 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-18 | MSV000089271 | MassIVE
ProteomicsRiboproteome remodelling during quiescence exit in Saccharomyces cerevisiae
Characterization of the riboproteome composition in quiescent cells and post-translational reactivation. To characterize ribosome heterogeneity during the exit from quiescence, the protein composition of ribosomal particles from stationary phase and nutrient-stimulated cells was assessed. A label-fr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-20 | PXD047386 | Pride
Mass spectrometry Ribosome Saccharomyces cerevisiae 
ProteomicsRibosomal protein S27A pseudogene 5 is involved in monosome related RNA translation
Pseudogenes are copies of already existing genes, and while their sequences resemble the original parental gene, they contain mutations which generally render them non-functional. However, recent advances in genome analysis suggest that pseudogenes can in fact be translated and have specific functio...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD047544 | Pride
Pseudogene Ribosome Ubiquitin Translation 
UnknownA single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Not available
S-EPMC10662448 | biostudies-literature
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