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GenomicsA pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here we discover and characterize the sets of lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47494 | biostudies-arrayexpress
TranscriptomicsImplications of high level pseudogene transcription in Mycobacterium leprae
Approximately half of M. lepraeâ??s transcriptome consists of inactive gene products. This has an impact on overall energy and resource consumption without potential benefit to this organism. However, multiple translational â??silencingâ?? mechanisms are present, reducing additional energy and resou...
ORGANISM(S): Mycobacterium leprae 
2010-06-24 | E-GEOD-17191 | biostudies-arrayexpress
ProteomicsFrancisella noatunensis subsp orientalis FNO12 pseudogene validation
Due to the detection of mRNA expression for several protein CDS annotated as pseudogenes in the results of the microarray experiment, a shotgun proteomic approach was applied to verify actual protein translation for each pseudogene in the genome of FNO12.
ORGANISM(S): Francisella noatunensis subsp. orientalis FNO12 
2019-05-27 | PXD012449 | Pride
Hdmse Pseudogene Fno 
GenomicsPseudogene RNAseq
RNA sequencing to validate findings of somatic pseudogenes acquired during cancer development
EGAS00001000606 | EGA
ProteomicsUBB Pseudogene 4 encodes novel ubiquitin variants
Post-translational modification by ubiquitin and ubiquitin-like modifiers proteins regulate cellular processes at almost every levels. Ubiquitin itself is encoded by four different genes, either as single copy of ubiquitin fused to ribosomal proteins, or by polyubiquitin precursors3. Early studies i...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014318 | Pride
Ubiquitin Lamin a Nucleolus Pseudogene 
ProteomicsRibosomal protein S27A pseudogene 5 is involved in monosome related RNA translation
Pseudogenes are copies of already existing genes, and while their sequences resemble the original parental gene, they contain mutations which generally render them non-functional. However, recent advances in genome analysis suggest that pseudogenes can in fact be translated and have specific functio...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD047544 | Pride
Pseudogene Ribosome Ubiquitin Translation 
GenomicsExpressed Pseudogenes in the Transcriptional Landscape of Human Cancers

In this study, we describe a systematic analysis of pseudogene 'transcription' from an RNA-Seq resource of 293 samples, from 13 cancer and normal tissue types. We observed a highly prevalent, genome-wide expression of pseudogenes that could be categorized as universally expressed or linea...

phs000525.v1.p1 | EGA
UnknownThe human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference.
Not available
S-EPMC2329642 | biostudies-literature
TranscriptomicsA pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here we discover and characterize the sets of lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including ...
ORGANISM(S): Mus musculus 
2013-08-05 | GSE47494 | GEO
TranscriptomicsA FTH1 gene:pseudogene:miRNA network regulates tumorigenesis in prostate cancer
Pseudogenes, non-coding homologs of protein-coding genes, were once considered non-functional evolutional relics. Recent studies have shown that pseudogene transcripts can regulate their parental transcripts by sequestering shared microRNAs, thus acting as competing endogenous RNAs (ceRNAs). In this...
ORGANISM(S): Homo sapiens 
2017-07-26 | GSE101837 | GEO
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