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UnknownPakSurg 1: determining the epidemiology and risk factors of surgical site infections in Pakistan-a multicentre, prospective cohort study.

Introduction

Surgical site infections (SSIs) are among the the most common postoperative complications, despite being highly preventable. Multiple studies have explored the incidence and risk factors of SSIs globally. However, nationally representative data capable of informing evidence-base...
S-EPMC10373700 | biostudies-literature
UnknownCompliance of smokeless tobacco supply chain actors and products with tobacco control laws in Bangladesh, India and Pakistan: protocol for a multicentre sequential mixed-methods study.

Introduction

South Asia is home to more than 300 million smokeless tobacco (ST) users. Bangladesh, India and Pakistan as signatories to the Framework Convention for Tobacco Control (FCTC) have developed policies aimed at curbing the use of tobacco. The objective of this study is to assess th...
S-EPMC7304837 | biostudies-literature
UnknownEffects of adverse childhood experiences on university students' ability to lead healthy lives: an exploratory qualitative study in Lahore, Pakistan.

Background

Adverse Childhood Experiences are a significant global public health concern as these experiences have adverse effects on all the health determinants.

Methods

The interpretive phenomenological research design was used to explore the implications of adverse childhood experie...
S-EPMC11492790 | biostudies-literature
UnknownThymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies.
Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1-29) was synthesized, and evaluated for in vitro thym...
S-EPMC6984732 | biostudies-literature
UnknownExploring the Healing Potential of Aqueous Extract of <i>Baccaurea ramiflora</i> Leaves in Inflammation: A Cytokine and Prostaglandin Modulator.
Baccaurea ramiflora is a common edible nutritious plant that has been associated with a variety of medicinal attributes. This study investigated the anti-inflammatory effects of the aqueous extract of B. ramiflora leaves (BrLAE) in a complete Freund's adjuvant (CFA) induced inflammator...
S-EPMC12102493 | biostudies-literature
UnknownGreen synthesis of coumarin derivatives using Bronsted acidic pyridinium based ionic liquid [MBSPy][HSO4] to control an opportunistic human and a devastating plant pathogenic fungus Macrophomina phaseolina.
An eco-friendly simple protocol has been devised for the preparation of coumarin derivatives using doubly Brønsted acidic task specific ionic liquid (TSIL) as a catalyst. Solvent-free conditions were employed for the reaction of different substituted phenols with β-ketoester in TSIL to produce corre...
S-EPMC9400593 | biostudies-literature
ProteomicsProteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology
The Ras-related Rap1A GTPase is implicated in pancreas β-cell insulin secretion, and is stimulated by the cAMP sensor Epac2, a guanine exchange factor and activator of Rap1 GTPase. In this study we examined the differential proteomic profiles by nanoLC-ESI-MS/MS of pancreata from C57BL/6 Rap1A-defic...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052896 | Pride
Oral glucose tolerance test  insulin tolerance test Glucose-stimulated insulin secretion Pancreas  intracellular signaling  rap1a-gtpase  gene knockout  differential expression  nanolc-esims/ms  ero1lβ expression 
UnknownUnderstanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Background

The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death.

Methods

The CRASH-3...
S-EPMC7657351 | biostudies-literature
UnknownReal-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology.

Background

Nosocomial respiratory virus outbreaks represent serious public health challenges. Rapid and precise identification of cases and tracing of transmission chains is critical to end outbreaks and to inform prevention measures.

Methods

We combined conventional surveillance with...
S-EPMC8653627 | biostudies-literature
UnknownCOVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group.
To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectiona...
S-EPMC10766674 | biostudies-literature
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