216755 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
MetabolomicsA metabolomics approach to unravel the regulating role of phytohormones towards carotenoid metabolism in tomato fruit. (beta-carotene)
Carotenoids are important secondary metabolites, which have been recognized as an essential component of the human diet because of their valuable beneficial health effects. With this rationale, there is a continuous aim to define the distribution of these compounds in plants, to better understand th...
2014-08-31 | MTBLS110 | MetaboLights
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
MetabolomicsUntargeted Metabolomics analysis of A549 treated with 0.5 mM extracellular ATP and 10 ng/ml TGF-beta
Not available
ORGANISM(S): Homo sapiens 
ST001779 | MetabolomicsWorkbench
ProteomicsA transphyletic study of metazoan β-catenin protein complexes
β-catenin plays a vital role in various biological processes, such as body axis determination and cell differentiation, during embryonic development in metazoans. These β-catenin functions are thought to be exerted through complexes formed with various types of proteins. Although β-catenin complex p...
ORGANISM(S): Cellular Organisms 
2025-01-21 | PXD053223 | JPOST Repository
TranscriptomicsNova1 is a master regulator of alternative splicing in pancreatic beta cells
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the M-bM-^@M-^\neuron spe...
ORGANISM(S): Rattus norvegicus 
2014-10-01 | E-GEOD-59633 | biostudies-arrayexpress
TranscriptomicsA Regulatory Pathway Involving Notch1/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate
The regulation of multipotent cardiac progenitor cell (CPC) expansion and subsequent differentiation into cardiomyocytes, smooth muscle, or endothelial cells is a fundamental aspect of basic cardiovascular biology and cardiac regenerative medicine. However, the mechanisms governing these decisions r...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-15232 | biostudies-arrayexpress
ProteomicsFungi hijack a plant apoplastic endoglucanase to release a ROS scavenging β-glucan decasaccharide to subvert immune responses
Plant pathogenic and beneficial fungi have evolved several strategies to evade immunity and cope with host-derived hydrolytic enzymes and oxidative stress in the apoplast, the extracellular spaces of plant tissues. Fungal hyphae are surrounded by an inner, insoluble cell wall layer and an outer, sol...
ORGANISM(S): Serendipita indica 
2022-08-12 | PXD025640 | Pride
Hordeum vulgare Soluble extracellular polysaccharide matrix Eps Serendipita indica Endophyte 
TranscriptomicsProgenitor Cell Marker Aldehyde Dehydrogenase 1a3 Defines a Subset of Failing Pancreatic Beta Cells in Diabetic Mice
Insulin-producing beta cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, sets the stage for progression from beta cell dysfunction to beta cell dedifferentiation. In this study, we sought to ...
ORGANISM(S): Mus musculus 
2016-09-02 | E-GEOD-78966 | biostudies-arrayexpress
ProteomicsInvestigating the Antifibrotic Effects of β-Citronellol on a TGF-β1-stimulated LX-2 Hepatic Stellate Cell Model
Liver fibrosis, a consequence of chronic liver damage or inflammation, is characterized by the excessive buildup of extracellular matrix components. This progressive condition significantly raises the risk of severe liver diseases like cirrhosis and hepatocellular carcinoma. The lack of approved the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-06 | PXD052806 | Pride
Hepatic stellate cell Citrus hystrix dc. Liver fibrosis Β-citronellol Proteomic analysis Lc-ms/ms 
ProteomicsImmunopeptidome of a human beta cell line infected by Coxsackievirus B strains
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β-cell autoimmunity. We investigated how CVB impacts human β cells and anti-CVB T-cell responses. β cells were efficiently infected by CVB in vitro, downregulated HLA Class I and presented few, selected HLA-bound viral peptide...
ORGANISM(S): Homo sapiens (Human) 
2023-08-19 | PXD042711 | Pride
Coxsackievirus Beta cells Immunopeptidome 
Sort   by:  
 Page size