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MetabolomicsBioactivities of Streptomyces spp. Against selected Oral Pathogens and In silico Streptenol B interaction on pgaB of Aggregatibacter actinomycetemcomitans
Periodontal disease is an inflammatory condition affecting the tissues supporting the teeth. Biofilm formation by oral pathogens such as Aggregatibacter actinomycetemcomitans (AA) and Pseudomonas aeruginosa (PA) contribute to persistent infections and antibiotic resistance. This study evaluated the ...
2026-06-23 | MTBLS14826 | MetaboLights
TranscriptomicsExpression analysis, A. actinomycetemcomitans wild type (JP2) vs CRP deletion mutant both grown anaerobically.
The goal of this analysis is to define the anaerobic regulon for the global transcription factor CRP (catabolite repressor protein) in the periodontal pathogen Aggregatibacter actinomycetemcomitans. The objectives were met by comparing the mRNA profile of a wild type strain, JP2, to that of an isoge...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2011-06-01 | E-GEOD-25459 | biostudies-arrayexpress
ProteomicsHistone-like family of nucleoid structuring protein of A. actinomycetemcomitans promotes biofilm formation and alters protein dynamics of other species within multi-species biofilm
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like...
ORGANISM(S): Candida albicans (Yeast) Aggregatibacter aphrophilus Streptococcus mutans Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum Veillonella dispar Actinomyces oris 
2018-06-05 | PXD008444 | Pride
Multi-species biofilm Hns A. actinomycetemcomitans Label-free quantification 
ProteomicsOuter membrane vesicle proteome of Aggregatibacter actinomycetemcomitans serotype e strain 173
Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis, and with endocarditis. Outer membrane vesicles (OMVs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (CDT) and l...
ORGANISM(S): Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) 
2015-09-21 | PXD002509 | Pride
Gram negative Aggregatibacter actinomycetemcomitans Outer membrane vesicles Lc-ms/ms 
TranscriptomicsComparative genomic analysis of Aggregatibacter actinomycetemcomitans of JP2 and non-JP2 genotypes using a pan-genome microarray
To assess the performance of our custom-designed pan-genome microarray and characterize the differences in gene content between JP2 and non-JP2 genotypes of A. actinomycetemcomitans. Comparative genomic hybridization reactions were carried out to assess the performance of our pan-genome microarray b...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2012-09-28 | E-GEOD-39143 | biostudies-arrayexpress
TranscriptomicsComparative genomic analysis of Aggregatibacter actinomycetemcomitans strains during short term persistent infections using a pan-genome microarray
To analyze the gain and lost of genes in Aggregatibacter actinomycetemcomitans during short-term persistent infection in the same host The microarray was used to compare gene contents of 4 different pairs of Aggregatibacter actinomycetemcomitans strains (SCC393 vs A160, SCC1398 vs SCC4092, SCC2302 v...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2013-12-31 | E-GEOD-42953 | biostudies-arrayexpress
TranscriptomicsAerobic v. anaerobic gene expression in Aggregatibacter actinomycetemcomitans
The opportunistic pathogen A. actinomycetemcomitans (Aa) expereinces fluctuating oxygen levels in its natural habitat, the gingival crevice of the human oral cavity. Since oxygen influences metabolic interactions between Aa and other oral microbes, we sought to characterize oxygen-dependent Aa gene ...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2014-02-01 | E-MTAB-2213 | biostudies-arrayexpress
TranscriptomicsExpression analysis of A. actinomycetemcomitans wild type (JP2) vs. Mlc deletion mutant both grown aerobically and anaerobically
The goal of this analysis is to define the aerobic and anaerobic regulons for the transcription factor Mlc (Makes Large Colonies) in the periodontal pathogen Aggregatibacter actinomycetemcomitans. The objectives were met by comparing the mRNA profile of a wild type strain, JP2, to that of an isogeni...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2013-06-01 | E-GEOD-38868 | biostudies-arrayexpress
GenomicsAggregatibacter actinomycetemcomitans
Multi locus sequence typing of A. actinomycetemcomitans
PRJNA633763 | ENA
ProteomicsDifferential virulence of Aggregatibacter actinomycetemcomitans serotypes explained by exoproteome heterogeneity
Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative bacterial pathogen associated with periodontitis and non-oral diseases like rheumatoid arthritis and Alzheimer´s disease. Aa isolates with the serotypes a, b and c are globally most prevalent. Importantly, isolates displaying these seroty...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2022-12-16 | PXD036160 | Pride
Aggregatibacter actinomycetemcomitans Virulence Exoproteome Serotype Infection 
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