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MetabolomicsMetabolic Rewiring of Bacterial Subpopulations Governs Polymyxin Responses in Acinetobacter baumannii
Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly Acinetobacter baumannii. However, most mechanistic studies to date have overlooked the heterogeneity within bacterial populations during polymyxin treatment. Using time-lapse imaging and propidiu...
2026-07-27 | MTBLS14745 | MetaboLights
MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
TranscriptomicsCharacterization of A. baumannii Mitomycin C (MMC) response
Transcriptional profiling of A. baumannii ATCC 17978 comparing treated-MMC cultures with non-MMC treated cultures Two-condition experiment A. baumannii 17978 MMC+ vs A. baumannii 17978 MMC-. Biological replicates:3, Technical replicates:2
ORGANISM(S): Acinetobacter baumannii ATCC 17978 
2013-11-14 | E-GEOD-44735 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of ATCC 17978hm Acineotbacter baumannii strain and CpdA mutant
Difference in RNA expression levels between Acinetobacter baumannii cells expressing high and low levels of cyclic AMP Total RNA obtained from Acineotbacter baumannii bacterial cells in Log phase gown in MH broth culture, isolated RNA in triplicate from three expreiment. cpdA::Tn mutant and 17978hm ...
ORGANISM(S): Acinetobacter baumannii 
2015-06-21 | E-GEOD-64935 | biostudies-arrayexpress
ProteomicsColistin resistance in Acinetobacter baumannii MDR-ZJ06 revealed by a multiomics approach
To explore how multiple drug-resistant A. baumannii response to colistin resistance, we compared the genomic, transcriptional and proteomic profile of A. baumannii MDR-ZJ06 to that of induced colistin resistant strain ZJ06-200P5-1.
ORGANISM(S): Acinetobacter baumannii 
2017-03-15 | PXD005265 | Pride
Colistin  acinetobacter baumannii 
TranscriptomicsTranscriptomic analysis of chlorhexidine shock in Acinetobacter baumannii
In this study the transcriptomic changes occurring in A. baumannii ATCC 17978 in response to shock treament using the biocide chlorhexdine were determined. A. baumannii ATCC 17978 cells were grown at 37°C with shaking (200rpm) in 35mL cultures in MH broth to OD600=0.75, at which time they were spli...
ORGANISM(S): Acinetobacter baumannii 
2013-12-03 | E-GEOD-51525 | biostudies-arrayexpress
TranscriptomicsColistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids and poly-beta-1,6-N-acetylglucosamine
We recently demonstrated that colistin resistance in Acinetobacter baumannii can result from mutational inactivation of genes essential for lipid A biosynthesis. Consequently, strains harboring these mutations are unable to produce the major Gram negative bacterial surface component, lipopolysacchar...
ORGANISM(S): Acinetobacter baumannii 
2011-08-11 | E-GEOD-31206 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of Acinetobacter baumannii ATCC 17978 to limiting iron availability
A. baumannii ATCC 17978 cells were incubated under iron replete (mueller-hinton) and iron limiting (MH + 200 µM 2,2'-dipyridyl) conditions, total RNA was extracted when cultures reached OD600=0.7. The probes on the microarray cover all predicted open reading frames (at least 4 per ORF) and addition...
ORGANISM(S): Acinetobacter baumannii 
2013-10-18 | E-GEOD-24921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acinetobacter baumannii multi-drug resistant strain and a susceptible reference strain - Abefflux
Transcriptomic comparison of a multidrug resistant Acinetobacter baumannii strain and a susceptible reference strain.
ORGANISM(S): Acinetobacter baumannii 
2009-11-20 | E-MEXP-2254 | biostudies-arrayexpress
ProteomicsSecretome of Acinetobacter baumannii KAB strains
We analyzed the extracellular proteome of colistin-resistant Korean Acinetobacter baumannii (KAB) strains to identify proteome profiles that can be used to characterize extensively drug-resistant KAB strains.
ORGANISM(S): Acinetobacter baumannii 
2020-05-27 | PXD015959 | Pride
Mrab Acinetobacter baumannii Secretome 
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