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GenomicsTranscriptomic analysis of AASS-knockdown H1299 cells to identify its role in metastatic potential of lung adenocarcinoma
Transcriptomic analysis of AASS-knockdown H1299 cells to identify its role in metastatic potential of lung adenocarcinoma
PRJEB102257 | ENA
TranscriptomicsTranscriptomic analysis of AASS-knockdown H1299 cells to identify its role in metastatic potential of lung adenocarcinoma
Through a metabolic RNAi-based screen for cell invasion, potential metastatic functions of AASS were identified. This study was to investigate the role of AASS and its metabolic product, α-aminoadipate (2-AAA), in the metastatic potential of lung adenocarcinoma. H1299 lung adenocarcinoma cells were ...
ORGANISM(S): Homo sapiens 
2026-02-28 | E-MTAB-16032 | biostudies-arrayexpress
ProteomicsProteomic Discovery of 2-AAA–Binding SAE1 and SUMO2/3-Related POLR2A
This dataset contains two types of proteomics experiments. First, we performed affinity-based pulldown assays using biotin-conjugated 2-aminoadipic acid (2-AAA) to identify proteins that directly bind to this metabolite. Second, we conducted SUMO1 or SUMO2/3 immunoprecipitation followed by LC-MS/MS ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-04 | PXD070076 | Pride
Sae1 2-aminoadipic acid (2-aaa) Polr2a Aass Lc-ms/ms 
UnknownStructure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase.
Not available
S-EPMC12086093 | biostudies-literature
UnknownTherapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice.
Not available
S-EPMC12848188 | biostudies-literature
UnknownAn inhibitory mechanism of AasS, an exogenous fatty acid scavenger: Implications for re-sensitization of FAS II antimicrobials.
Not available
S-EPMC11271967 | biostudies-literature
UnknownIntegrative analysis of mitochondrial and immune pathways in diabetic kidney disease: identification of AASS and CASP3 as key predictors and therapeutic targets.
Not available
S-EPMC11852243 | biostudies-literature
UnknownTargeting AASS alleviates neurotoxicity and improves mitochondrial function in astrocyte models for pyridoxine-dependent epilepsy.
Not available
S-EPMC12554910 | biostudies-literature
UnknownNext generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly.
Not available
S-EPMC7569139 | biostudies-literature
GenomicsTargeting AASS improves neurotoxicity and mitochondrial function in astrocyte models for pyridoxine dependent epilepsy
Targeting AASS improves neurotoxicity and mitochondrial function in astrocyte models for pyridoxine dependent epilepsy
PRJNA1211642 | ENA
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