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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic analysis of AASS-knockdown H1299 cells to identify its role in metastatic potential of lung adenocarcinoma

ABSTRACT: Through a metabolic RNAi-based screen for cell invasion, potential metastatic functions of AASS were identified. This study was to investigate the role of AASS and its metabolic product, α-aminoadipate (2-AAA), in the metastatic potential of lung adenocarcinoma. H1299 lung adenocarcinoma cells were infected with a pLKO.1-based lentiviral vector carrying shRNA targeting AASS. Poly-A RNA sequencing was then performed on control and AASS-knockdown H1299 cells to assess differentially expressed genes modulated by AASS depletion.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: KIYOUNG EUN

PROVIDER: E-MTAB-16032 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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