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AATF is a predominantly nuclear protein that has been shown to be an apoptosis-inhibiting factor essential for both embryonic development and tumor growth. Several studies have shown a role of AATF in the modulation of pivotal cellular signal transduction pathways such as p53-, mTOR- and HIF-signali...
ORGANISM(S): Homo sapiens (Human) 
2019-08-13 | PXD011055 | Pride
Multiple myeloma is a hematological neoplasm of plasma cells characterized by an abnormal production of immunoglobulins. Che-1/AATF (Che-1) is an RNA binding protein involved in transcription regulation and highly expressed in this malignancy. In order to better characterize its functions in this ty...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026659 | Pride
ChIP-seq following AATF in BIU-87 cells
Effect of AATF silencing on gene expression of BIU-87 [RNA-seq]
Human nephronophthisis and related ciliopathies suggest a link between ciliary signaling defects and altered DNA damage responses. The goal of our study is to elucidate the molecular link of both signaling systems as well as the role of altered DNA damage responses in kidney degeneration and fibrosi...
ORGANISM(S): Mus musculus 
AATF silencing suppresses tumor progression by reprogramming the microenvironment in hepatocellular carcinoma
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