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UnknownMiconazole Mitigates Acetic Acid-Induced Experimental Colitis in Rats: Insight into Inflammation, Oxidative Stress and Keap1/Nrf-2 Signaling Crosstalk.
Ulcerative colitis (UC) is the most common type of inflammatory bowel disease, characterized by oxidative stress and elevated pro-inflammatory cytokines. Miconazole is an azole antifungal that stimulates the expression of antioxidant enzymes via Nrf2 activation, which consequently inhibits ROS forma...
S-EPMC8869207 | biostudies-literature
UnknownMetabolomics Panel Associated with Cystic Fibrosis-Related Diabetes toward Biomarker Discovery.
The most prevalent comorbidity among cystic fibrosis (CF) patients is cystic fibrosis-related diabetes (CFRD). CFRD has been linked to one of the worse clinical outcomes and a higher mortality. Improved clinical results have been related to earlier diagnosis and treatment of CFRD. Therefore, the pre...
S-EPMC11292812 | biostudies-literature
UnknownNeuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Direct activation of the endocannabinoid receptor G protein-coupled receptor 18 (GPR18) in the rostral ventrolateral medulla (RVLM) of conscious rats by abnormal cannabidiol (Abn CBD; trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) elevates local nitric oxide (NO) ...
S-EPMC4165025 | biostudies-literature
UnknownStudy of the association between a MICA gene polymorphism and cholangiocarcinoma in Egyptian patients.

Introduction

An inflammatory environment is the common pathway for the development of cholangiocarcinoma (CCA). The natural killer group 2D receptor (NKG2D), an activating receptor for NK cells, is a potent immune axis in the antitumor and antimicrobial immune response through its binding to...
S-EPMC9850301 | biostudies-literature
UnknownEstrogen Receptors α and β Play Major Roles in Ethanol-Evoked Myocardial Oxidative Stress and Dysfunction in Conscious Ovariectomized Rats.

Background

We documented the dependence of ethanol (EtOH)-evoked myocardial dysfunction on estrogen (E2 ), and our recent estrogen receptor (ER) blockade study, in proestrus rats, implicated ERα signaling in this phenomenon. However, a limitation of selective pharmacological loss-...
S-EPMC5272804 | biostudies-literature
UnknownStabilization benefits of single and multi-layer self-nanoemulsifying pellets: A poorly-water soluble model drug with hydrolytic susceptibility.
Solidified self-nanoemulsifying drug delivery systems (SNEDDS) offer strong option to enhance both drug aqueous solubility and stability. The current study was designed to evaluate the potential stabilization benefits of solidifying cinnarizine (CN) liquid SNEDDS into single and multi-layer self-nan...
S-EPMC6053139 | biostudies-literature
ProteomicsProteomics profiling to distinguish DOCK8 deficiency from atopic dermatitis
Background: DOCK8 deficiency is an autosomal recessive form of hyperimmunoglobulinemia E syndrome (HIES). Severe atopic dermatitis (AD) shares with DOCK8 deficiency some clinical symptoms, including eczema, eosinophilia, and increased serum IgE levels. The deficiency of DOCK8 protein is potentially ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-17 | PXD029052 | Pride
Atopic dermatitis Multiple-reaction monitoring Label-free proteomics Lc-mse synaptg2 Dedicator of cytokinesis (dock8) Hyper ige syndrome (hies) 
UnknownEstrogen-mediated mitigation of cardiac oxidative stress in ovariectomized rats is associated with upregulated cardiac circadian clock Per2 and heart-specific miRNAs.

Aim

Estrogen (E2) confers cardioprotection in premenopausal women and in models of menopause and its effects, mostly studied in female reproductive organs, vary on a circadian rhythm basis in relation to the circadian clock genes. However, it remains unknown if a similar circadian pattern ex...
S-EPMC10528738 | biostudies-literature
UnknownComparison between platelet rich fibrin as space filling material versus xenograft and alloplastic bone grafting materials in immediate implant placement: a randomized clinical trial.

Background

This study aimed to compare the efficacy of different gap filling materials in immediate implant in anterior and premolar regions of maxilla.

Materials and methods

Thirty-six implants were inserted in patients seeking for replacement of non-restorable maxillary anterior and...
S-EPMC10704731 | biostudies-literature
UnknownEstrogen receptor α activation enhances its cell surface localization and improves myocardial redox status in ovariectomized rats.

Aims

Little is known about the role of subcellular trafficking of estrogen receptor (ER) subtypes in the acute estrogen (E2)-mediated alleviation of oxidative stress. We tested the hypothesis that ERα migration to the cardiac myocyte membrane mediates the acute E2-depen...
S-EPMC5535783 | biostudies-literature
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