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GenomicsMapping Epigenomic Type-Specific Differences Occurring During Hematopoiesis [ChIP-Seq]
Formation of the blood from self-renewing hematopoietic stem cells to terminal lineages necessarily involves epigenomic modifications of the genome to control regulator and signature gene expression. By analysing the global expression profiles of hematopoietic stem cells (HSCs), in vivo differentiat...
ORGANISM(S): Homo sapiens 
2013-03-25 | E-GEOD-39538 | biostudies-arrayexpress
TranscriptomicsMapping Epigenomic Type-Specific Differences Occurring During Hematopoiesis
Formation of the blood from self-renewing hematopoietic stem cells to terminal lineages necessarily involves epigenomic modifications of the genome to control regulator and signature gene expression. By analysing the global expression profiles of hematopoietic stem cells (HSCs), in vivo differentiat...
ORGANISM(S): Homo sapiens 
2013-03-25 | E-GEOD-39229 | biostudies-arrayexpress
TranscriptomicsMapping Epigenomic Type-Specific Differences Occurring During Hematopoiesis [RNA-Seq]
Formation of the blood from self-renewing hematopoietic stem cells to terminal lineages necessarily involves epigenomic modifications of the genome to control regulator and signature gene expression. By analysing the global expression profiles of hematopoietic stem cells (HSCs), in vivo differentiat...
ORGANISM(S): Homo sapiens 
2013-03-25 | E-GEOD-39537 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (RNA-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-73859 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (CLIP-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-68196 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (GRO-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-68197 | biostudies-arrayexpress
UnknownEWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
Not available
S-EPMC5846483 | biostudies-literature
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
TranscriptomicsTargeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [Gene Expression]
Global gene expression after CDK7 inhibition by THZ1 Global gene expression after genetic knockdown or overexpression of MYCN
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-62724 | biostudies-arrayexpress
GenomicsChromatin profiling reveals novel proteins associated with histone-marked genomic regions
Our understanding of the functions of DNA elements is limited by the paucity of information about the spectrum of proteins that occupy these genomic regions. Here we describe an approach to identify proteins associated with genomic regions whose chromatin is marked by specific modified histones, whi...
ORGANISM(S): Mus musculus 
2015-02-05 | E-GEOD-62380 | biostudies-arrayexpress
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