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ProteomicsAcarbose Primarily Targets Intracellular GH97 Enzymes in Bacteroides to Impair Their Growth
The type 2 diabetes drug acarbose inhibits starch breakdown into glucose by host gluco(amylases) in the upper gastrointestinal tract. Acarbose is poorly absorbed by host tissue and transits to the large intestine with undigested starch. Numerous gut species in the Bacteroides genus break down starch...
ORGANISM(S): Bacteroides ovatus ATCC 8483 
2024-10-18 | PXD052070 | Pride
Acarbose  alpha-amylase  glucosidase  glycoside hydrolase family 13  glycoside hydrolase family 97  bacteroidota 
ProteomicsThe expression of the acarbose biosynthetic gene cluster of Actinoplanes sp. SE50/110 is dependent on the growth phase
Actinoplanes sp. SE50/110 produces the diabetes type II drug acarbose only during the growth phase and not in the stationary phase. This correlation between the course of the cell growth and the biosynthesis could be due to a decreasing expression of the acarbose biosynthesis genes until the station...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2021-09-09 | PXD017973 | Pride
Acarbose Proteomics Co-regulation Transcriptomics Actinoplanes sp. se50/110 Expression dynamics 
OtherComprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.
Data from ProteomeXchange, PXD ID: PXD001497. Experiment: SW_Exo_G2, file: 130519_o3_p4_ao_SW_Exo_G2_8.mzml. Published as part of J Proteomics. 2015 Jul 1;125:1-16 . From the Abstract: {{i}} Acarbose is an α-glucosidase inhibitor produced by Actinoplanes sp. SE50/110 that is medically importan...
ORGANISM(S): Actinoplanes_sp_se50_110 
GPM32320019694 | GPMDB
Resource Reanalysis 
TranscriptomicsAcarbose improves obesity-induced insulin resistance and immune homeostasis by directly regulating gut microbiota and macrophages inflammation
Acarbose was reported to alleviate obesity-induced insulin resistance IR and regulate the gut microbiota community; however, the critical microbial signaling metabolites and the host targets associated with the metabolic benefits of acarbose remains unknown. In this study, we reported that acarbose ...
ORGANISM(S): Mus musculus 
2024-11-04 | GSE232578 | GEO
GenomicsAcarbose improves obesity-induced insulin resistance and immune homeostasis by directly regulating gut microbiota and macrophages inflammation
Acarbose improves obesity-induced insulin resistance and immune homeostasis by directly regulating gut microbiota and macrophages inflammation
PRJNA972753 | ENA
UnknownMolecular insights of acarbose metabolization catalyzed by acarbose-preferred glucosidase.
Not available
S-EPMC12373829 | biostudies-literature
ProteomicsAcarbose improves late-life physical function in mice of both sexes, but rejuvenates cardiac structure and lipid profile in males only
With an expanding aging population burdened with comorbidities, there is considerable interest in treatments that optimize health in later life. Acarbose (ACA), a drug used clinically to treat Type 2 diabetes (T2DM) can extend mouse lifespan, with greater effect in males than in females. Utilizing a...
ORGANISM(S): Mus Musculus 
2021-03-03 | PXD017706 | panorama
Genomics
gut microbiota after Acarbose treatment
PRJNA1124223 | ENA
TranscriptomicsTime-course transcriptome data of Actinoplanes sp. SE50/110 during the whole process of acarbose fermentation
Metabolic engineering for high-value compounds like acarbose, a type 2 diabetes drug, requires systematic understanding of metabolic regulation. Here, we integrated multi-dimensional systems biology approach in Actinoplanes sp. SE50/110, a non-model bacterium producing acarbose. First, we reconstruc...
ORGANISM(S): Actinoplanes 
2026-04-01 | GSE312767 | GEO
Genomics
gut microbiota after Acarbose treatment
PRJNA1123668 | ENA
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