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TranscriptomicsTranscription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment ...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2739 | biostudies-arrayexpress
ProteomicsSARS-Cov2 coronavirus spike protein-induced apoptosis, inflammatory and oxidative stress responses in THP-1-Like-Macrophages: potential role of angiotensin converting enzyme inhibitor (perindopril)
A purified spike (S) glycoprotein for SARS-COV-2 coronavirus was used to studying its effects on THP-1 macrophages, PBMCs and HUVEC cells. The S protein mediates SARS-CoV-2 entry into cells through binding to angiotensin converting enzyme 2 (ACE2) receptors. We measured viability, intracellular cyto...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2021-11-16 | PXD025516 | Pride
Sars-cov-2 spike protein  monocyte/macrophages  inflammation  angiotensin converting enzyme inhibitor  proteomics 
UnknownRecent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It.
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S-EPMC8651430 | biostudies-literature
UnknownLosartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands.
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S-EPMC6530859 | biostudies-literature
UnknownIntrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
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S-EPMC3009920 | biostudies-literature
UnknownAngiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update.
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S-EPMC7908946 | biostudies-literature
UnknownCYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
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S-EPMC2995375 | biostudies-literature
UnknownClassical and Counter-Regulatory Renin-Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology.
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S-EPMC8046706 | biostudies-literature
UnknownRole of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model.
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S-EPMC2117227 | biostudies-literature
UnknownPotassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats.
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S-EPMC6804396 | biostudies-literature
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