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MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
GenomicPGRN-RIKEN: Identification of Genetic Predictors of ACE Inhibitor-Associated Angioedema

The purpose of this study is to identify genetic predictors of ACE inhibitor-associated angioedema. In addition to preventing the formation of the pressor angiotensin II, ACE inhibitors prevent the carboxyl-terminal degradation of the vasoactive substances bradykinin and substance P. Angioedema i...

phs000438 | dbGaP
ProteomicsBeta-blocker/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts.
Rationale: The molecular underpinnings of heart failure with reduced ejection fraction (HFrEF) involves a complex remodeling of the contractile, metabolic and electrical functions. Current pharmacotherapy for patients presenting HFrEF includes combination of angiotensin-converting enzyme inhibitors ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD024525 | Pride
Ace inhibitor Hfref Cardiac proteomics ß-ar blocker Phosphoproteomics 
TranscriptomicsTranscription profiling of mouse aorta genes of APOE-deficient animals receiving the ACE inhibitor captopril
Microarray gene expression profiling of aorta genes of APOE-deficient mice receiving atherosclerosis treatment with the ACE inhibitor captopril. Hypercholesterolemic APOE-deficient mice were used as a standard model of atherosclerosis to study gene expression changes during atherosclerosis treatment...
ORGANISM(S): Mus musculus 
2009-12-14 | E-GEOD-19286 | biostudies-arrayexpress
ProteomicsLC-MS/MS identification and sequence analysis of ACE inhibitory peptides derived from bovine hemoglobin
This project contains raw MS data and database search files for the identification and sequence analysis of ACE inhibitory peptides derived from bovine hemoglobin using LC-MS/MS. The data includes original mass spectrometry files and corresponding search results for peptide identification and sequen...
ORGANISM(S): Bos Taurus 
2026-03-27 | PXD076229 |
TranscriptomicsHippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in prote...
ORGANISM(S): Mus musculus 
2013-05-14 | GSE46871 | GEO
TranscriptomicsACE-Scan of the thrombin DNA aptamer on 10^10 Gen1 DNA microarrays with sodium and potassium buffers in two colors.
The experiments were carried out to map the ligand binding landscape of various DNA and RNA duplexed aptamer families. Duplexed Aptamer (DA) constructs were engineered from (i) natural and synthetic DNA and RNA aptamers and (i) synthetic oligonucleotide aptamer-complementary elements synthesized on ...
ORGANISM(S): synthetic construct 
2017-12-20 | E-MTAB-6378 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiling of aorta genes of APOE-deficient mice receiving the ACE inhibitor captopril
Microarray gene expression profiling of aorta genes of APOE-deficient mice receiving atherosclerosis treatment with the ACE inhibitor captopril. Hypercholesterolemic APOE-deficient mice were used as a standard model of atherosclerosis to study gene expression changes during atherosclerosis treatment...
ORGANISM(S): Mus musculus 
2009-12-03 | GSE19286 | GEO
ProteomicsProteomic analysis of human macrophages overexpressing angiotensin-converting enzyme
Angiotensin converting enzyme (ACE) exerts strong modulation of myeloid cell function independently of its cardiovascular arm. The success of the ACE-overexpressing murine macrophage model, ACE 10/10, in treating microbial infections and cancer opens a new venture into whether ACE overexpression in ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD052292 | Pride
Ace Swath Protein inhibitor Angiotensin Protein function 
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