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ProteomicsInhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance
Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell activation is negatively regulated by C-terminal Src kinase (CSK); however, the exact mechanism remains unknown....
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037546 | Pride
Phosphotyrosine Immune checkpoint blockade Ack1 Prostate cancer Src 
GenomicsRole of ACK1 condensates in STAT5 activation in LUSC cells
Role of ACK1 condensates in STAT5 activation in LUSC cells
PRJNA1213808 | ENA
GenomicsT Cell Reinvigoration upon ACK1/TNK2 inhibition Overcomes Immune Resistance
T Cell Reinvigoration upon ACK1/TNK2 inhibition Overcomes Immune Resistance
PRJNA872199 | ENA
TranscriptomicsRole of ACK1 condensates in STAT5 activation in LUSC cells
ACK1 is a non-receptor tyrosine kinase that phosphorylates multiple substrates involved in cancer progression. Additional regulatory mechanisms governing ACK1 activity remain to be elucidated. We demonstrate that ACK1 is frequently amplified and overexpressed in lung squamous cell carcinoma (LUSC). ...
ORGANISM(S): Homo sapiens 
2025-07-02 | GSE287607 | GEO
GenomicsResponse of human iPSCs-derived macrophages to apoptotic cells, role of ACK1 and BRK tyrosine kinases
Response of human iPSCs-derived macrophages to apoptotic cells, role of ACK1 and BRK tyrosine kinases
PRJNA486609 | ENA
UnknownIdentification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Not available
S-EPMC5731862 | biostudies-literature
UnknownCancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.
Not available
S-EPMC2856269 | biostudies-literature
TranscriptomicsT Cell Reinvigoration upon ACK1/TNK2 inhibition Overcomes Immune Resistance
Solid tumors are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of the effector T cells and its trafficking back to the tumor. The T cell activation is negatively regulated by C-terminal Src kinase (CSK), however, the exact mechanism of CSK’s T cell-...
ORGANISM(S): Homo sapiens 
2022-09-01 | GSE211835 | GEO
UnknownAck1: activation and regulation by allostery.
Not available
S-EPMC3544672 | biostudies-literature
UnknownPhosphorylation of Ack1 by the Receptor Tyrosine Kinase Mer.
Not available
S-EPMC10473914 | biostudies-literature
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