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MetabolomicsA Bidirectional Regulatory ACLY-NLRP3 Axis Integrates Metabolic and Inflammatory Signaling to Control NLRP3 Inflammasome Activation

The NLRP3 inflammasome is critical for host defense against bacterial infection and is involved in the pathogenesis of various inflammatory diseases. The aggregation of its sensor protein NLRP3 is a pivotal checkpoint for inflammasome activation. Howev...

2026-01-07 | MTBLS13400 | MetaboLights
TranscriptomicsACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxi...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-61286 | biostudies-arrayexpress
MetabolomicsGlutaminolysis contribution to the carbon backbone of aspartate through ATP Citrate Lyase (ACLY) in ccRCC
Not available
ORGANISM(S): Homo sapiens 
ST002221 | MetabolomicsWorkbench
ProteomicsThe proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in glioblastoma and remodel...
ORGANISM(S): Homo sapiens (Human) 
2024-07-29 | PXD054314 | Pride
Acss2 Fatty acid synthesis Acly 
TranscriptomicsExpression data by ACLY knockdown
De novo lipogenesis is activated in most cancers. Several lipogenic enzymes are implicated in oncogenesis and represent potential cancer therapeutic targets. RNA interference-mediated depletion of ATP citrate lyase (ACLY), the enzyme that catalyzes the first step of de novo lipogenesis, leads to gro...
ORGANISM(S): Homo sapiens 
2014-04-13 | E-GEOD-37243 | biostudies-arrayexpress
GenomicsRole of ACLY in gene regulation during adipocyte differentiation
Role of ACLY in gene regulation during adipocyte differentiation
PRJNA493228 | ENA
GenomicsRegulation of NK effector function by ACLY-generated acetylation [CUT&Tag]
Regulation of NK effector function by ACLY-generated acetylation [CUT&Tag]
PRJNA1208935 | ENA
GenomicsEffect of ACLY inhibition on LPS-induced EC gene profiles
Effect of ACLY inhibition on LPS-induced EC gene profiles
PRJNA892518 | ENA
GenomicsRegulation of NK effector function by ACLY-generated acetylation [RNA-Seq]
Regulation of NK effector function by ACLY-generated acetylation [RNA-Seq]
PRJNA1209397 | ENA
GenomicsHepatic ACLY deficiency and bempedoic acid drive divergent responses to dietary lipid
Hepatic ACLY deficiency and bempedoic acid drive divergent responses to dietary lipid
PRJNA1037152 | ENA
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