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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
MetabolomicsACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma
Not available
ORGANISM(S): Mus musculus 
ST002241 | MetabolomicsWorkbench
GenomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [ChIP-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and directchum regulator of histone acetylation in neurons and of long-term mamma...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76850 | biostudies-arrayexpress
ProteomicsACSS2 Upregulation Enhances Neuronal Resilience to Aging and Neurodegeneration
Epigenetic mechanisms, including histone acetylation, play a key role in learning and memory, with recent evidence of a role in neuronal function in Alzheimer’s disease and Related Dementia (ADRD). Acetyl-CoA sythetase 2 (ACSS2) is central to epigenetics and gene regulation, particularly in neurons,...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD048769 | Pride
Acss2 Aging Neuron Neurodegeneration 
ProteomicsUsing proximity labeling by turboID (biotin ligase) fused with ACSS2 combined with LC-MS for identification of the proteins associated with ACSS2 in oncogene RAS activation induced senescent human IMR90 cell
Senescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. The metabolic enzyme ACSS2 produces acetyl-coA from acetate and ep...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD048937 | Pride
Human Imr90 Lc-ms 
TranscriptomicsAcetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, however the mechanisms are largely unknown. We show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a critical and direct regulator of histone acetylation in neurons and of long-term mammalian...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-76853 | biostudies-arrayexpress
ProteomicsKRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation
Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental analysis of common KRAS mutations suggest that each mutation...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD050157 | Pride
Colorectal cancer Kras Acss2 
GenomicsACSS2 modulates endothelial glycolysis in angiogenesis
ACSS2 modulates endothelial glycolysis in angiogenesis
PRJNA1285789 | ENA
ProteomicsThe proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in glioblastoma and remodel...
ORGANISM(S): Homo sapiens (Human) 
2024-07-29 | PXD054314 | Pride
Acss2 Fatty acid synthesis Acly 
GenomicsACSS2 modulates endothelial glycolysis in angiogenesis [Cut&Tag]
ACSS2 modulates endothelial glycolysis in angiogenesis [Cut&Tag]
PRJNA1469548 | ENA
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