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GenomicsGene expression data from IMR90 Control, IMR90 HRAS-G12V, IMR90 HRAS-G12V+shDOT1L, IMR90 DOT1L Overexpression
Gene expression data from IMR90 Control, IMR90 HRAS-G12V, IMR90 HRAS-G12V+shDOT1L, IMR90 DOT1L Overexpression
PRJNA658579 | ENA
GenomicsDNA Methylation in IMR90 cells
DNA methylation was measured by MBD2 enrichment of DNA fragments in IMR90. A statistical model was developed to estimate absolute methylation levels, and compared to whole genome bisulfite sequencing results (Lister, R. et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38679 | biostudies-arrayexpress
ProteomicsPhosphorylation level of SIRT1 in proliferating and senescent IMR90 cells
Mammalian SIRT1 is a central regulator of metabolism and aging. This project is to analyze global phosphorylation levels of mammalian SIRT1 in proliferating and senescence states using human lung fibroblast IMR90, in order to explore the post-translational regulation of SIRT1 protein upon cellular s...
ORGANISM(S): Homo sapiens (Human) 
2020-09-29 | PXD020081 | Pride
Imr90 Senescence Sirt1 Phosphorylation 
GenomicsNucleosome positioning in the IMR90 cell line
Micrococcal nuclease (Mnase) treatment and sequencing of mononucleosomal DNA One single sample in the IMR90 fibroblast cell line
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-44985 | biostudies-arrayexpress
TranscriptomicsRNA-seq in HepG2 and IMR90 cells
Expression analysis in HepG2 and IMR90 cells in presence of Fluc siRNA or sPom121 or Nup98 siRNA Transfect siRNA - extract RNA 72 hrs post transfection
ORGANISM(S): Homo sapiens 
2016-06-22 | E-GEOD-83551 | biostudies-arrayexpress
ProteomicsNuclear protein expression profiling of IMR90 RAS cells compared to IMR90 Control cells
One-third of all human cancers are attributable to mutations in RAS. Induction of oncogenic RAS during tumorigenesis leads to metabolic reprogramming and enhanced proliferation or senescence. These profound phenotypic changes require adaptations in gene expression, RNA processing, and protein synthe...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD035299 | Pride
Hrasg12v Nuclear proteins Ras Imr90 Senescence 
TranscriptomicsIMR90 DDR
Transcription profiling of IMR90 fibroblasts after ionizing radiation. Cells were harvested 30 minutes (acute response) or 5 days (cell cycle arrested) after being irradiated with 5Gy of ionizing radiation.
ORGANISM(S): Homo sapiens 
2014-06-17 | E-MTAB-2088 | biostudies-arrayexpress
GenomicsNucleosome map of the IMR90 fibroblast cell line
We produced a map of nucleosome positions in IMR90 by sequencing the ends of MNase-digested chromatin fragments. IMR90 cells were grown in culture, about 1E6 cells were isolated and digested using micrococcal nuclease (MNase). Mononucleosomes were gel-selected and fragment ends were sequenced using ...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-21823 | biostudies-arrayexpress
TranscriptomicsIMR90 hTERT
Transcription profiling from young and pre-senescent IMR90 cells, transfected either with hTERT (pBabe-puro-hTERT) or vector control (pBabe-puro). Population doubling values are contained in Characteristics[generation] column.
ORGANISM(S): Homo sapiens 
2014-06-17 | E-MTAB-2087 | biostudies-arrayexpress
GenomicsGenome-wide profiling of H3K27ac (ChIP-seq) in IMR90 cells
To determine the genome-wide pattern of H3K27ac in IMR90 (ATCC CCL-186) cells we performed ChIP-seq upon hormone treatment (1.5 h, 1 M dexamethasone).
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5355 | biostudies-arrayexpress
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