Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA), is central in driving ferroptosis. Here, we reveal that ...
We found Acsl mutants have deficient neuroblast development. Further experiment confirmed that genes related to cell cycle and pluripotency were supressed in Acsl mutants.
