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ProteomicsiTRAQ-Based Quantitative Proteomics Analysis of the Effect of ACT001 on Non-alcoholic Steatohepatitis in Mice
Non-alcoholic steatohepatitis (NASH) is considered a progressive stage of non-alcoholic fatty liver disease (NAFLD) that can progress to cirrhosis and hepatocellular carcinoma. ACT001 is a novel sesquiterpene lactone derivative that has been shown to have significant antitumor and anti-inflammatory ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-17 | PXD035890 | Pride
Non-alcoholic steatohepatitis Inflammation Proteomics Act001 Itraq 
TranscriptomicsTargeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
Glioblastoma (GBM) is the most lethal primary brain tumor in adults with a median survival of around 15 months. A potential treatment strategy involves targeting glioma stem-like cells (GSCs) that are able to initiate, maintain, and repopulate the tumor mass. Here, we identify ACT001, a parthenolide...
ORGANISM(S): Homo sapiens 
2020-09-11 | GSE157779 | GEO
GenomicsTargeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
PRJNA662736 | ENA
UnknownACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain.
Not available
S-EPMC9218074 | biostudies-literature
UnknownACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma.
Not available
S-EPMC7254983 | biostudies-literature
UnknownACT001 inhibits the proliferation of non-small cell lung cancer cells by upregulating NKTR expression.
Not available
S-EPMC9200889 | biostudies-literature
UnknownACT001 Inhibits Tumor Progression and Modulates Immune Responses in Non-Small Cell Lung Cancer.
Not available
S-EPMC12423771 | biostudies-literature
UnknownTargeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling.
Not available
S-EPMC7738851 | biostudies-literature
UnknownACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma.
Not available
S-EPMC6779874 | biostudies-literature
UnknownACT001 alleviates MASLD through gut microbiota-bile acid-FXR axis in mice.
Not available
S-EPMC12599161 | biostudies-literature
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