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ProteomicsMulti-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma patients – proteins from serum samples of melanoma patients with high tumor load
Pathophysiology of cancer-associated syndroms such as cachexia is poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-31 | MSV000083385 | MassIVE
ProteomicsMulti-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma patients - proteins from serum samples of healthy donors
Pathophysiology of cancer-associated syndroms such as cachexia is poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004626 | Pride
Serum analysis Metastatic melanoma Shotgun proteomics Calcium mobilization Mass spectrometry Platelet activation Cachexia Damage signature 
ProteomicsMulti-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma patients - proteins from serum samples of melanoma patients with low tumor load
Pathophysiology of cancer-associated syndroms such as cachexia is poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004625 | Pride
Serum analysis Metastatic melanoma Shotgun proteomics Calcium mobilization Mass spectrometry Platelet activation Cachexia Damage signature 
ProteomicsMulti-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma patients – proteins from serum samples of melanoma patients with high tumor load
Pathophysiology of cancer-associated syndroms such as cachexia is poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004624 | Pride
Serum analysis Metastatic melanoma Shotgun proteomics Calcium mobilization Mass spectrometry Platelet activation Cachexia Damage signature 
ProteomicsCombinatory shotgun proteomics and shotgun eicosadomics study of platelets activated by calcium mobilization - secreted proteins of platelets stimulated for 3h with ionomycin
Platelets are involved in relevant physiological and pathophysiological processes such as hemostasis and tumor progression. These anucleate blood particles exert their functions essentially by releasing effector molecules such as proteins from intracellular granules and by generating and secreting s...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD005054 | Pride
Shotgun proteomics and eicosadomics Secretomes Human platelets Lysates Mass spectrometry Activation by calcium mobilization 
TranscriptomicsIL-33 induces a hypo-responsive human mast cell phenotype
Interleukin-33 (IL-33) is elevated in afflicted tissues of patients with mast cell-dependent chronic allergic diseases. Based on its acute effects on mouse mast cells (MCs), IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress
UnknownKynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35.
Not available
S-EPMC9606686 | biostudies-literature
TranscriptomicsT Cell Receptor-Induced NF-kB Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-Mediated Calcium Entry
T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular calcium (Ca2+) to activate the key transcription factors NFAT and NF-κB. The mechanism of NFAT activation by Ca2+ has been determined; however, the role of Ca2+ in controlling NF-κB ...
ORGANISM(S): Homo sapiens 
2016-01-14 | E-GEOD-76804 | biostudies-arrayexpress
UnknownDematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets.
Not available
S-EPMC10251785 | biostudies-literature
MetabolomicsSuccinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

Succinate is implicated in rheumatoid arthritis (RA) and other inflammatory diseases via its receptor, G protein-coupled receptor 91 (GPR91). Despite its therapeutic potential, conflicting reports on its inflammatory roles have hindered GPR91-targeted treatm...

2026-02-05 | MTBLS13828 | MetaboLights
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