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MetabolomicsMicrobiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated meta...

2026-05-09 | MTBLS13787 | MetaboLights
TranscriptomicsRNA-seq of vastus lateralis muscle biopsies of newly diagnosed treatment-naïve NSCLC patients with cachexia and age-matched and sex-matched healthy controls
Cancer cachexia, highly prevalent in lung cancer, is a debilitating syndrome characterized by involuntary loss of skeletal muscle mass, and is associated with poor clinical outcome, decreased survival and negative impact on on tumor therapy. Here we sought to identify the muscle gene profile and pat...
ORGANISM(S): Homo sapiens 
2023-04-03 | E-MTAB-12781 | biostudies-arrayexpress
ProteomicsHaptoglobin and glutamine synthetase as potential biomarkers of chemotherapy-induced cachexia in skeletal muscle
Cancer cachexia is a multifactorial wasting syndrome affecting body and lean tissue mass that is often exacerbated by anticancer chemotherapy. In this study, we used a mouse model of acute myeloid leukemia chemotherapy induction regimen (CIR) comprising daunorubicin and cytarabine to investigate the...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD063910 | Pride
Cancer cachexia Proteomics Skeletal muscle wasting Glutamine synthetase Tmt Mitochondrial metabolism Acute myeloid leukemia Haptoglobin Chemotherapy Biomarkers Aml 
MetabolomicsMetabolites changes related to glucose-mediated energy production in chemotheraphy-induced cachexia
Not available
ORGANISM(S): Mus musculus 
ST001467 | MetabolomicsWorkbench
TranscriptomicsLeukemia Inhibitory Factor in C26 Cancer Cachexia
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer. C2C12 myotubes treated with conditioned mediu...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-68827 | biostudies-arrayexpress
MetabolomicsSphingolipid Concentrations in Serum for Muscle Wasting in Cancer Cachexia (part-IX)
Not available
ORGANISM(S): Homo sapiens 
ST001014 | MetabolomicsWorkbench
MetabolomicsTCA Concentrations in Serum for Muscle Wasting in Cancer Cachexia (part-VIII)
Not available
ORGANISM(S): Homo sapiens 
ST001013 | MetabolomicsWorkbench
MetabolomicsNEFA Panel in Serum for Muscle Wasting in Cancer Cachexia (part-VI)
Not available
ORGANISM(S): Homo sapiens 
ST001011 | MetabolomicsWorkbench
ProteomicsProteomic comparison study between cancer cachexia muscle of C26 and CT mice
Background Loss of skeletal muscle mass in advanced cancer is recognized as an independent predictor of mortality. Mechanisms involved in this wasting process and parameters for early diagnosis are still lacking. As skeletal muscle is considered as a secretory organ, the aim of this present experime...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD016474 | Pride
Cancer Biomarkers C26 mice Cachexia Muscle Atrophy 
MetabolomicsNEFA Panel in Muscle Tissue of Muscle Wasting in Cancer Cachexia (part-V)
Not available
ORGANISM(S): Homo sapiens 
ST001010 | MetabolomicsWorkbench
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