Sort   by:  
 Page size 
MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsColonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice
The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphat...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
TranscriptomicsChronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts
Using a novel flood source construct, we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast cultures to acute (10cGy and 200cGy) and longer-term chronic (1.0-2.45cGy cumulative over 24hr) exposures. Samples were colle...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-52918 | biostudies-arrayexpress
TranscriptomicsComparison of mouse genes from the lungs of chronic, acute, tolerant, and non-asthmatic mouse models
Microarray analysis of whole lung tissue from three mouse models of asthma Acute asthma was produced by immunization twice, one week apart, of Balb/C mice 8-12 weeks of age with Aspergillus species (5 μg) in adjuvant (1:1 vol/vol). Adjuvant was aluminum and magnesium hydroxide (Pierce). Asthma was i...
ORGANISM(S): Mus musculus 
2014-02-15 | E-GEOD-54297 | biostudies-arrayexpress
TranscriptomicsFibrogenic and redox-related but not proinflammatory genes are upregulated in lewis rat model of chronic silicosis
Silicosis, a fibrotic granulomatous lung disease, may occur through accidental high-dose or occupational inhalation of silica, leading to acute/accelerated and chronic silicosis, respectively. While chronic silicosis has a long asymptomatic latency, lung inflammation and apoptosis are hallmarks of a...
ORGANISM(S): Rattus norvegicus 
2012-01-01 | E-GEOD-29110 | biostudies-arrayexpress
ProteomicsSerum Peptidome: Diagnostic Window into Pathogenic Processes following Occupational Exposure to Carbon Nanomaterials
Growing industrial use of carbon nanotubes and nanofibers (CNT/F) warrants consideration of human health outcomes. CNT/F produces pulmonary, cardiovascular, and other toxic effects in animals, with significant augmentation of bioactive circulating peptides, the serum peptidome. While epidemiology am...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-26 | MSV000087305 | MassIVE
ProteomicsDifferential modification of the C. elegans proteome in response to acute and chronic gamma radiation: link with reproduction decline
Ecosystems are chronically exposed to ionizing radiations. But environmental risk assessment of chronic exposure suffers from a lack of knowledge. Extrapolation of data from acute to chronic exposure is not always relevant, and can lead to uncertainties. In fact, effects could be different between t...
ORGANISM(S): Caenorhabditis elegans 
2020-10-15 | PXD011731 | Pride
Gamma radiation Lc-ms Label-free quantification Caenorhabditis elegans 
TranscriptomicsSmall Marine Neurotoxin Elicits Common Antibody Response in Zebrafish and Sea Lions
The neurotoxic amino acid, domoic acid, is naturally produced by marine phytoplankton and presents a significant health threat to marine mammal and human populations. Currently, diagnostic tools to assess exposure are not available, yet concerns regarding health impacts associated with low-level re...
ORGANISM(S): Danio rerio 
2013-01-03 | E-GEOD-34716 | biostudies-arrayexpress
TranscriptomicsInfluence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)
Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of a...
ORGANISM(S): Pimephales promelas 
2008-04-06 | E-GEOD-8404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat chronic exposure to cigarette smoke
Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, w...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7079 | biostudies-arrayexpress
Sort   by:  
 Page size