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Metabolomic analysis was conducted on serum samples from acute ischemic stroke (AIS) patients to identify altered metabolites.

2026-01-21 | MTBLS11987 | MetaboLights
Hemorrhagic transformation (HT), which occurs with or without reperfusion treatments (thrombolysis and/or thrombectomy), deteriorates the outcomes of ischemic stroke patients. It is essential to find clinically reliable biomarkers that can predict HT. In this study, we screened for potential serum b...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD026950 | Pride
Recruit patients with first-ever acute ischemic stroke (AIS) and classify them into two study groups based on the presence or absence of vitamin B12 deficiency, while also including a matched healthy control group. Utilize 4D-DIA proteomics technology to analyze the protein expression profiles and i...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD062264 | Pride
Objective Acute ischemic stroke is a group of diseases characterized by high morbidity, high disability, high mortality, and high recurrence, and most patients are left with varying degrees of sequelae. Symptomatic intracranial atherosclerotic stenosis (sICAS) is a major cause of acute ischemic stro...
ORGANISM(S): Homo Sapiens 
Gene expression profiles in microglia with or without PGC-1α overexpression after acute ischemic stroke (AIS)
CircRNA as Predictive Biomarker of Penumbra in Acute Ischemic Stroke
TMT-coupled proteomic analysis was conducted on mouse brain cortex tissue from five time-points up to four weeks post-stroke in the DH-MCAO mouse model. Nearly-half of the detected proteome was altered following stroke, with <10% of changes at relatively large scales. Clustering on the changed prote...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-10 | PXD025077 | Pride
Identification of Blood Circular RNAs as the Potential Biomarkers for Acute Ischemic Stroke
To predict acute ischemic stroke (AIS) in large-artery atherosclerosis (LAA), we combined serum proteomics with machine learning to identify diagnostic biomarkers. Using a dual-cohort design, we analyzed proteins and validated targets through advanced proteomic techniques. Machine learning identifie...
ORGANISM(S): Homo Sapiens 
2025-03-11 | PXD061679 |
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