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ProteomicsDiurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism
Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promote circadian misalignment and metabolic disease but the underlying mechanisms remain unknown. Post-translational modifications have emerged as key regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-07 | PXD066863 | Pride
Quantitative proteomics Acsf3 Mouse Circadian rhythms Acyl-coa synthetase 3 Silac Liver Lysine-malonylation 
ProteomicsDiurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism
Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promote circadian misalignment and metabolic disease but the underlying mechanisms remain unknown. Post-translational modifications have emerged as key regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD066866 | Pride
Quantitative proteomics Acsf3 Mouse Circadian rhythms Silac Liver 
GenomicsDiurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism
Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism
PRJNA1463862 | ENA
TranscriptomicsMicroarray expression profiling of C. elegans N2 L4 control (RNAi) vs. nhr-25 (RNAi) and N2 (Wt) vs. acs-3 (ft5) mutants
Acyl-coA synthases (ACSs) produce fatty acyl-CoAs that are used in metabolic and signaling pathways. Metazoans have a large number of ACS genes with differing expression patterns and substrate preferences, but the physiological roles of most ACS genes are unknown. Here, we focused on the C. elegans ...
ORGANISM(S): Caenorhabditis elegans 
2014-03-21 | E-GEOD-48605 | biostudies-arrayexpress
TranscriptomicsDiurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism
Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promote circadian misalignment and metabolic diseases but the underlying mechanisms remain scarce. Post-translational modifications have emerged as key regu...
ORGANISM(S): Mus musculus 
2026-07-07 | GSE330452 | GEO
UnknownSuppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.
Not available
S-EPMC2781602 | biostudies-literature
UnknownEnhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids.
Not available
S-EPMC4493641 | biostudies-literature
UnknownActivity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.
Not available
S-EPMC2868784 | biostudies-literature
UnknownFatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
Not available
S-EPMC4981512 | biostudies-literature
UnknownA short-chain acyl-CoA synthetase that supports branched-chain fatty acid synthesis in Staphylococcus aureus.
Not available
S-EPMC10026030 | biostudies-literature
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