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ProteomicsSystematic substrate identification reveals a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer’s disease amyloid precursor protein. ADAM10 is also req...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD003426 | Pride
Neurons Adam10 substrates Protease Bioorthogonal chemistry 
ProteomicsIn vitro sheding activity of ADAM10
Investigation of the shading activity of the recombinant catalytic domain of ADAM10
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD040511 | Pride
Adam10 app alzheimer’s disease 
ProteomicsTetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex
A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a ‘molecular scissor’ that proteolytically cleaves the extracellular region from over 100 substrates, including Notch, amyloi...
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD016508 | Pride
Tspan15 Adam10 
UnknownTspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.
Not available
S-EPMC4819958 | biostudies-literature
ProteomicsDegradome of soluble ADAM10 and ADAM17 metalloproteases
Disintegrin and metalloproteinases ADAM10 and ADAM17 can release the extracellular region of a variety of membrane-bound proteins including cytokines, adhesion molecules, growth factors and receptors, important for many biological functions (ectodomain shedding).. So far, substrate identification fo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-06-24 | PXD013718 | Pride
Lc-ms Tails Metalloproteases 
UnknownStructural basis for membrane-proximal proteolysis of substrates by ADAM10.
Not available
S-EPMC10528452 | biostudies-literature
UnknownProteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.
Not available
S-EPMC1489169 | biostudies-literature
UnknownThe Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors.
Not available
S-EPMC8910667 | biostudies-literature
UnknownDegradome of soluble ADAM10 and ADAM17 metalloproteases.
Not available
S-EPMC11105009 | biostudies-literature
UnknownNrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
Not available
S-EPMC6460357 | biostudies-literature
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