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ProteomicsTargeting the CDS1/2 axis as a therapeutic strategy in uveal melanoma and pan-cancer
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and combin...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD053752 | Pride
Cds1 Cds2 Uveal melanom 
UnknownFixation using alternative implants for the treatment of hip fractures (FAITH-2): design and rationale for a pilot multi-centre 2 × 2 factorial randomized controlled trial in young femoral neck fracture patients.
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S-EPMC6540373 | biostudies-literature
UnknownThe synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.
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S-EPMC12283370 | biostudies-literature
UnknownBlood-based protein biomarkers for diagnosis of Alzheimer disease.
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S-EPMC6287606 | biostudies-literature
UnknownImpact of the COVID-19 Pandemic on the Implementation of Mobile Health to Improve the Uptake of Hydroxyurea in Patients With Sickle Cell Disease: Mixed Methods Study.
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S-EPMC9578525 | biostudies-literature
UnknownCOVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study.
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S-EPMC9240087 | biostudies-literature
UnknownA novel Alzheimer disease locus located near the gene encoding tau protein.
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S-EPMC4573764 | biostudies-literature
UnknownInterleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
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S-EPMC7953461 | biostudies-literature
UnknownSurgical ablation of atrial fibrillation during mitral-valve surgery.
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S-EPMC4664179 | biostudies-literature
UnknownHuman and mouse essentiality screens as a resource for disease gene discovery.
Not available
S-EPMC6994715 | biostudies-literature
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