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MetabolomicsFunctional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

Metabolic flexibility is key to survival and growth in all living organisms. In mammals, the pathways supporting cell proliferation in nutrient-limiting conditions have not been fully elucidated, although certain tumors display metabolic dependencies that can be targeted for therapy. He...

2026-02-02 | MTBLS13799 | MetaboLights
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15524 | MetaboLights
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
MetabolomicsMetabolomics Analysis: Opioid Addiction Project (Golestan Cohort Study) - NMR (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001619 | MetabolomicsWorkbench
MetabolomicsMetabolomics Analysis: Opioid Addiction Project (Golestan Cohort Study) - MS (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001618 | MetabolomicsWorkbench
MetabolomicsTAp73 is a marker of glutamine addiction in medulloblastoma
Not available
ORGANISM(S): Homo sapiens 
ST000898 | MetabolomicsWorkbench
GenomicsStabilized biological production by product addiction
Populations of engineered metabolite-producing microorganisms are prone to evolutionary production declines during industrial-scale cultivations. In this study, we develop a synthetic product addiction system in E coli that addicts mevalonic acid production cells to mevalonic acid. Through experimen...
ORGANISM(S): Escherichia coli K-12 
2018-02-09 | E-MTAB-6182 | biostudies-arrayexpress
ProteomicsAn oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies
Oncogene addiction provides important therapeutic opportunities for precision oncology treatment strategies. To date the cellular circuitries associated with driving oncoproteins, which eventually establish the phenotypic manifestation of oncogene addiction remain largely unexplored. We employed a t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037406 | Pride
Oncogene addiction Phosphosignature Human Selected reaction monitoring 
GenomicGenome-Wide Analysis for Addiction Susceptibility Genes

Genome wide analysis for addiction susceptibility genes is an affected sibling pair linkage study using subjects who were patients in methadone replacement treatment programs (MMTP). Such patients are highly addicted to opioids and usually to other addicting substances as well. For entry into th...

phs001266 | dbGaP
TranscriptomicsPrefrontal cortex gene expression in WSP and WSR male and female mice following 72h of chronic ethanol vapor exposure
Ethanol is the most common substance of abuse in the US, and abuse can lead to physical dependence, addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. As a comple...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-56247 | biostudies-arrayexpress
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